1332526-89-2Relevant academic research and scientific papers
INDAZOLE COMPOUNDS USEFUL AS KETOHEXOKINASE INHIBITORS
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Page/Page column 36-37, (2011/11/06)
The present invention is directed to substituted indazole compounds, pharmaceutical compositions of these compounds and methods of use thereof. The compounds of the present invention are ketohexokinase (KHK) inhibitors, useful for treating or ameliorating a KHK mediated metabolic disorders and/or diseases such as obesity, Type II diabetes mellitus and Metabolic Syndrome X.
Optimization of a pyrazole hit from FBDD into a novel series of indazoles as ketohexokinase inhibitors
Zhang, Xuqing,Song, Fengbing,Kuo, Gee-Hong,Xiang, Amy,Gibbs, Alan C.,Abad, Marta C.,Sun, Weimei,Kuo, Lawrence C.,Sui, Zhihua
, p. 4762 - 4767 (2011/09/16)
A series of indazoles have been discovered as KHK inhibitors from a pyrazole hit identified through fragment-based drug discovery (FBDD). The optimization process guided by both X-ray crystallography and solution activity resulted in lead-like compounds with good pharmaceutical properties.
