133258-35-2

Upstream product

• 114433-96-4 2-[4-bromo-5-(4-fluoro-phenyl)-3-(1-methylethyl)-1H-pyrazol-1-yl]pyridine 
• 140-88-5 ethyl acrylate 
• 114433-95-3 2-[5-(4-fluorophenyl)-3-(1-methylethyl)-1H-pyrazol-1-yl]pyridine 
• 114433-94-2 1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione 
• 4930-98-7 pyrid-2-ylhydrazine 

Downstream Products

• 141046-41-5 2-hydroxy-1,2,2-triphenylethyl *,R^*-(E)>>-5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate 
• 141046-43-7 1,1-dimethylethyl -7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-5-hydroxy-3-oxo-6-heptenoate 
• 141046-44-8 1,1-dimethylethyl *,S^*-(E)>>-7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3,5-dihydroxy-6-heptenoate 
• 133258-38-5 ethyl (E)-7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-5-hydroxy-3-oxo-6-heptenoate 
• 141046-42-6 methyl -5-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-3-hydroxy-4-pentenoate 
• 133258-37-4 (E)-3-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-2-propenal 
• 133258-36-3 (E)-3-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-2-propen-1-ol 

Relevant academic research and scientific papers

Inhibitors of cholesterol biosynthesis. 6. trans-6-[2-(2-N-heteroaryl-3,5- disubstituted-pyrazol-4-yl)ethyl/ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-ones

A series of N-heteroaryl-substituted mevalonolactones were prepared and evaluated for their ability to inhibit the enzyme HMG-CoA reductase both in vitro and in vivo, and to lower plasma cholesterol in a hypercholesterolemic dog model. The goal of the str