133261-11-7

Basic information

• Product Name: ethyl 3-cyclopropyl-1-methyl-1H-pyrazole-5-carboxylate
• Synonyms: ethyl 3-cyclopropyl-1-methyl-1H-pyrazole-5-carboxylate;1H-Pyrazole-5-carboxylic acid, 3-cyclopropyl-1-methyl-, ethyl ester
• CAS NO: 133261-11-7
• Molecular Formula: C₁₀H₁₄N₂O₂
• Molecular Weight: 194
• Mol File: 133261-11-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 315.0±30.0 °C(Predicted)
• Appearance: /
• Density: 1.26±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.97±0.10(Predicted)
• CAS DataBase Reference: ethyl 3-cyclopropyl-1-methyl-1H-pyrazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-cyclopropyl-1-methyl-1H-pyrazole-5-carboxylate(133261-11-7)
• EPA Substance Registry System: ethyl 3-cyclopropyl-1-methyl-1H-pyrazole-5-carboxylate(133261-11-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 133261-11-7(Hazardous Substances Data)

Usage

General Description

Ethyl 3-cyclopropyl-1-methyl-1H-pyrazole-5-carboxylate is a chemical compound with the molecular formula C11H15N3O2. It is a ester derivative of pyrazole carboxylic acid, and is often used as an intermediate in organic synthesis. ethyl 3-cyclopropyl-1-methyl-1H-pyrazole-5-carboxylate has a cyclopropyl and a methyl group attached to the pyrazole ring, giving it unique properties and potential applications in pharmaceuticals and agrochemicals. It may also have biological activity, making it of interest for research and development in the fields of medicine and agriculture. Additionally, it is important to handle and store this compound carefully, as it may be hazardous if not used properly.

Upstream product

• 21080-80-8 ethyl 4-cyclopropyl-2,4-dioxobutanoate 
• 60-34-4 methylhydrazine 
• 765-43-5 Cyclopropyl methyl ketone 

Downstream Products

• 1171921-06-4 (3-cyclopropyl-1-methyl-1H-pyrazol-5-yl)methanol 
• 136283-92-6 C₈H₉ClN₂O 
• 957500-07-1 3-cyclopropyl-1-methyl-1H-pyrazole-5-carboxylic acid 

Relevant articles and documents

Design, synthesis, DFT study and antifungal activity of the derivatives of pyrazolecarboxamide containing thiazole or oxazole ring

Pyrazolecarboxamide fungicides are one of the most important classes of agricultural fungicides, which belong to succinodehydrogenase inhibitors (SDHIS). To discover new pyrazolecarboxamide analogues with broad spectrum and high activity, a class of new compounds of pyrazole carboxamide derivatives containing thiazole or oxazole ring were designed by scaffold hopping and bioisosterism, and 36 pyrazole carboxamide derivatives with antifungal activity were synthesized. Those compounds were evaluated against five phytopathogenic fungi, Gibberella zeae, Phytophythora capsici, Sclerotonia sclerotiorum, Erysiphe graminis and Puccinia sorghi. The results indicated that most of the compounds displayed good fungicidal activities, especially against E. graminis. Theoretical calculations were carried out at the B3LYP/6-31G (d, p) level and the full geometry optimization was carried out using the 6-31G (d, p) basis set, and the frontier orbital energy, atomic net charges, molecular docking were discussed, and the structure-activity relationships were also studied.

Synthesis of fluorinated and nonfluorinated tebufenpyrad analogues for the study of anti-angiogenesis MOA

In this contribution we report the synthesis of fluorinated and nonfluorinated tebufenpyrad analogues to explore potential druglike properties through the phenotypic screening as part of the Lilly Open Innovation Drug Discovery (OIDD) program.