133261-33-3

Basic information

• Product Name: TRANS-4-(TRIFLUOROMETHYL)CYCLOHEXANECARBOXYLIC ACID
• Synonyms: TRANS-4-(TRIFLUOROMETHYL)CYCLOHEXANECARBOXYLIC ACID;(1R,4R)-4-(TrifluoroMethyl)cyclohexanecarboxylic acid;Cyclohexanecarboxylic acid,4-(trifluoromethyl)-,trans-;trans-4-(Trifluoromethyl)cyclohexanecarboxylic Acid;trans-4-(trifluoromethyl)cyclohexane-1-carboxylic acid;TRANS-4-(TRIFLUOROMETHYL)CYCLOHEXANECARBOXYLICACIID
• CAS NO: 133261-33-3
• Molecular Formula: C₈H₁₁F₃O₂
• Molecular Weight: 196.1669496
• Product Categories: 4-Substituted Cyclohexanecarboxylic Acids;Aliphatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 133261-33-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 154 °C
• Boiling Point: 233.5°C at 760 mmHg
• Flash Point: 95°C
• Appearance: /
• Density: 1.292g/cm³
• Vapor Pressure: 0.0194mmHg at 25°C
• Refractive Index: 1.421
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 4.60±0.10(Predicted)
• CAS DataBase Reference: TRANS-4-(TRIFLUOROMETHYL)CYCLOHEXANECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: TRANS-4-(TRIFLUOROMETHYL)CYCLOHEXANECARBOXYLIC ACID(133261-33-3)
• EPA Substance Registry System: TRANS-4-(TRIFLUOROMETHYL)CYCLOHEXANECARBOXYLIC ACID(133261-33-3)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 7/9-26-36/37/39-45
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 133261-33-3(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 133261-33-3 differently. You can refer to the following data:
1. A cyclic haloalkyl substituted carboxylic acid, trans-4-(TrifluoroMethyl)cyclohexanecarboxylic Acid can be used in the preparation of antiviral agents.
2. A cyclic haloalkyl substituted carboxylic acid used in the preparation of antiviral agents.

InChI:InChI=1/C8H11F3O2/c9-8(10,11)6-3-1-5(2-4-6)7(12)13/h5-6H,1-4H2,(H,12,13)/t5-,6-

Upstream product

• 455-24-3 4-trifluoromethylbenzoic acid 

Downstream Products

• 133261-34-4 trans-4-(trifluoromethyl)cyclohexane-1-carbaldehyde 
• 1204296-05-8 methyl 4-trifluoromethylcyclohexanecarboxylate 
• 1621225-45-3 6-(((R)-1-cyclobutylethyl)amino)-7-((trans-4-(trifluoromethyl)cyclohexyl)methyl)-7H-purine-2-carbonitrile 
• 1621225-44-2 2-chloro-N-((R)-1-cyclobutylethyl)-7-((trans-4-(trifluoromethyl)cyclohexyl)methyl)-7H-purin-6-amine 
• 1621225-42-0 2,6-dichloro-7-((trans-4-(trifluoromethyl)cyclohexyl)methyl)-7H-purine 
• 1621225-43-1 3-methyl-7-((trans-4-(trifluoromethyl)cyclohexyl)methyl)-1H-purine-2,6(3H,7H)-dione 
• 133261-36-6 trans-1-(bromomethyl)-4-(trifluoromethyl)cyclohexane 
• 1360622-01-0 N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide 
• 1242269-83-5 N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(2,2-difluoro-ethoxy)-4-methylamino-5-amino-benzoic acid amide 

Relevant articles and documents

Electrocatalytic hydrogenation of benzoic acids in a proton-exchange membrane reactor

The highly efficient chemoselective electrocatalytic hydrogenation of benzoic acids (BAs) to cyclohexanecarboxylic acids (CCAs) was carried out in a proton-exchange membrane reactor under mild conditions without hydrogenation of the carboxyl group. Among the investigated catalysts, the PtRu alloy catalyst was found to be the most suitable for achieving high current efficiencies for production of CCAs. An electrochemical spillover mechanism on the PtRu alloy catalyst was also proposed.

Method for synthesizing cis-trifluoromethylcyclohexane derivatives and heterocyclic compounds by hydrogenation

The invention discloses a method for synthesizing cis-trifluoromethylcyclohexane derivatives and heterocyclic compounds by hydrogenation. The method is characterized in that trifluoromethylaromatic hydrocarbons or trifluoromethyl heterocyclic compounds ar