133261-34-4

Upstream product

• 133261-33-3 trans-4-trifluoro-methyl-cyclohexanecarboxylic acid 
• 926-62-5 isobutylmagnesium bromide 
• 934330-05-9 trans-4-(trifluoromethyl)cyclohexanecarbonyl chloride 
• 1202577-61-4 ((1r,4r)-4-(trifluoromethyl)cyclohexyl)methanol 
• 75091-99-5 4-(trifluoromethyl)cyclohexan-1-one 

Relevant academic research and scientific papers

THERAPEUTIC COMPOUNDS AND METHODS OF USE

The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

BICYCLIC COMPOUND ACTING AS ROR INHIBITOR

A bicyclic compound acting as a RORγ inhibitor. Provided are a compound of formula (I) or a pharmaceutically acceptable salt thereof, the compound having a structure as represented by formula (I-A) or formula (I-B). The provided compound of formula (I-A)

CYCLIC AMINE DERIVATIVE AND MEDICAL USE THEREOF

A cyclic amine derivative represented by general Formula (I): wherein R1 represents an alkyl group having 1 to 3 carbon atoms; A represents a group represented by general Formula (II-1), (II-2), or (II-3): R2 represents a hydrogen at

Thioamide-substituted dihydropyrrolopyridine compounds as ROR[gamma] inhibitors

The invention relates to thioamide-substituted dihydropyrrolopyridine compounds as ROR[gamma] inhibitors. The compounds represented by the formula (I) or pharmaceutically acceptable salts thereof havegood ROR[gamma] inhibitory activity and are expected to

3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF

The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein R1, R2, Rx, X1, n, n1, and q are as defined herein, and methods of making and using same.

DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA

Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by RORy. Also provided are pharmaceutical compositions co

Nematic liquid crystals with a tetrafluoroethylene bridge in the mesogenic core structure

A dramatic increase of the clearing temperatures of liquid crystals based on bis(cyclohexyl)ethane 1 by 50 to 70 K can be achieved by the perfluorination of the central ethylene link. Conformational analysis indicates that this effect is due to the increased rigidity of the mesogenic core structure and to the suppression of conformers with a bent shape. Materials based on bis(cylohexyl)tetrafluoroethane 2 might play a crucial role as materials for the next generation of active matrix LCDs with reduced power consumption.

Trifluoromethylcyclohexane derivatives

Disclosed are trifluoromethylcyclohexane derivatives of the formula I STR1 wherein R is an alkyl or alkenyl radical having up to 18 C atoms which is unsubstituted or substituted by CN or by at least one halogen, and in which one or more non-adjacent CH2 groups may be replaced by a radical selected from the group comprising --O--, --S--, --CO--, --O--CO--, --CO--O-- and --C C--, A1 and A2 are each, independently of one another, a) a 1,4-phenylene radical, in which one or two CH groups may be replaced by N, b) a 1,4-cyclohexylene radical, in which one or two non-adjacent CH2 groups may be replaced by --O-- or --S--, c) a 1,4-cyclohexenylene, piperidine-1,4-diyl, 1,4-bicyclo[2,2,2]-octylene or naphthalene-2,6-diyl radical, it being possible for the radicals a) and b) to be monosubstituted or polysubstituted by halogen atoms or cyano and/or methyl groups, STR2 Z1 and Z2 are each, independently of one another, --CO--O--, --O--CH--, --CH2 CH2 --, --CH(CN)--CH2 --, --CH2 --CH(CN)--, --CH=CH--, --OCH 2 --, --CH2 O--, --CH=N--, --N=CH--, --NO=N--, --N=NO--, --N=N-- or a single bond, and o is 0, 1 or 2. These compounds can be used as components of liquid-crystalline media for electrooptical display elements, in particular for matrix liquid-crystal displays.