133262-79-0Relevant articles and documents
Synthesis of a series of potent and orally bioavailable thrombin inhibitors that utilize 3,3-disubstituted propionic acid derivatives in the P3 position
Tucker, Thomas J.,Lumma, William C.,Dale Lewis,Gardell, Stephen J.,Lucas, Bobby J.,Sisko, Jack T.,Lynch, Joseph J.,Lyle, Elizabeth A.,Baskin, Elizabeth P.,Woltmann, Richard F.,Appleby, Sandra D.,Chen, I.-Wu,Dancheck, Kimberley B.,Naylor-Olsen, Adel M.,Krueger, Julie A.,Cooper, Carolyn M.,Vacca, Joseph P.
, p. 3687 - 3693 (1997)
As part of an effort to prepare efficacious and orally bioavailable analogs of the previously reported thrombin inhibitors 1a,b, we have synthesized a series of compounds that utilize 3,3-disubstituted propionic acid derivatives as P3 ligands.
