133267-39-7

Basic information

• Product Name: Acetamide, 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-, (S)-
• Synonyms: Acetamide, 2-amino-N-[(2S)-2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]- (9CI);Acetamide, 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-, (S)-
• CAS NO: 133267-39-7
• Molecular Weight: 0
• Mol File: 133267-39-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Acetamide, 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-, (S)-(133267-39-7)
• EPA Substance Registry System: Acetamide, 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-, (S)-(133267-39-7)

Safety Data

• Hazardous Substances Data: 133267-39-7(Hazardous Substances Data)

Upstream product

• 176851-43-7 N-(2-(2,5-Dimethoxyphenyl)-2-hydroxyethyl)-2-((1,1-dimethylethoxy)carbonylamino)essigsaeureamid 
• 60407-53-6 1-(2',5'-dimethoxyphenyl)-2-aminoethanol hydrochloride 

Relevant articles and documents

Organobase-catalyzed amidation of esters with amino alcohols

A base-mediated procedure for the amidation of unactivated esters with amino alcohols is reported. Optimization and exemplification of the catalytic process are described, furnishing products in 40-100% isolated yield.

A process for the preparation of midodrine

The invention provides a process for the preparation of 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide of the formula 1 by hydrogenolysis of substituted 2-dibenzylamino-N-[2-(2',5'-dimethoxyphenyl)-2-hydroxy-ethyl]acetamide having the formula (5), wherein Ar and Ar' are aryl groups.