133271-03-1

Upstream product

• 60340-28-5 (R)-1-phenyl-hex-5-en-3-ol 
• 104-53-0 3-phenyl-propionaldehyde 
• 95679-57-5 tert-butyl 5-phenyl-3-oxopentanoate 

Downstream Products

• 135943-81-6 (+)-(4S,6R)-8-phenyloct-1-ene-4,6-diol 
• 86117-01-3 (4R,6R)-(+)-4-hydroxy-6-(2-phenylethyl)-tetrahydro-2H-pyran-2-one 
• 286474-94-0 (4S,6R)-4-(2-propenyl)-6-(2-phenylethyl)-2,2-dimethyl-1,3-dioxane 

Relevant academic research and scientific papers

Alkyl 2-(2-benzothiazolylsulfinyl)acetates as useful synthetic reagents for alkyl 4-hydroxyalk-2-enoates by sulfinyl-Knoevenagel reaction

Isopropyl, ethyl, and methyl 2-(2-benzothiazolylsulfinyl)acetates have been found to be useful synthetic reagents for sulfinyl-Knoevenagel reaction with various aldehydes to give directly the corresponding 4-hydroxyalk-2-enoates [R′CH(OH)CHCHCO2R], which are ubiquitous structures in biologically active natural products and useful building blocks for organic synthesis of chiral compounds. From the optically pure (R)-2-(2- benzothiazolylsulfinyl)acetates (>99% ee) prepared by the enzymatic kinetic resolution of (±)-2-(2-benzothiazolylsulfinyl)acetates, optically active 4-hydroxyalk-2-enoates (up to 91% ee) have been obtained in good yields.

Enantioselective allyltitanation. Application to the synthesis of lactone units related to compactin and mevinolin

The enantioselective convergent synthesis of two different models of the lactone units of compactin and mevinolin was achieved using two consecutive enantioselective allyltitanations of aldehydes.

Enantioselective synthesis of syn- and anti-1,3-diols via allyltitanation of unprotected β-hydroxyaldehydes

(Formula presented) Syn- or anti-1,3-diols units were synthesized with excellent diastereomeric excess from unprotected chiral β-hydroxyaldehydes by using an enantioselective allyltitanation.