133271-14-4Relevant academic research and scientific papers
Novel enantioselective direct aldol-type reaction promoted by a chiral phosphine oxide as an organocatalyst
Kotani, Shunsuke,Shimoda, Yasushi,Sugiura, Masaharu,Nakajima, Makoto
supporting information; experimental part, p. 4602 - 4605 (2009/10/26)
Chiral phosphine oxide successfully catalyzed the direct aldol-type reactions of cyclohexanone derivatives and benzaldehyde derivatives in high stereoselectivities. The reaction mechanism involves the in situ formation of trichlorosilyl enol ethers. The present reaction could be extended to the cross-aldol reactions between two aldehydes.
