133282-00-5Relevant academic research and scientific papers
Mechanistic details of amino acid catalyzed two-component Mannich reaction: experimental study backed by density functional calculations
Rani, Dixita,Thakur, Lalita,Khera, Mayank,Goel, Neetu,Agarwal, Jyoti
, p. 1609 - 1621 (2019/11/20)
The role of pH-dependent ionic structures of l-amino acids in catalysis has been investigated for the two-component Mannich reactions between dimethyl malonate (DMM)/ethyl acetoacetate (EAA) and imines. As catalysts, l-amino acids performed well, even bet
Solvent-free synthesis of β-hydroxy esters and β-amino esters by indium-mediated reformatsky reaction
Chen, Xi'an,Zhang, Changfu,Wu, Huayue,Yu, Xiaochun,Su, Weike,Cheng, Jiang
, p. 3233 - 3239 (2008/09/16)
In a convenient and efficient procedure for the solvent-free synthesis of β-hydroxy esters and β-amino esters, various aldehydes and aldimines undergo a Reformatsky reaction mediated by non-activated indium at room temperature to give the corresponding esters in good to excellent yields. Georg Thieme Verlag Stuttgart.
Mannich-type reaction catalyzed by dicyanoketene ethylene acetal and the related polymer-supported π-acid: Aldimine-selective reactions in the coexistence of aldehydes
Tanaka, Nobuyuki,Masaki, Yukio
, p. 406 - 408 (2007/10/03)
Mannich-type reaction of aldimines and enolsilyl ethers proceeded with excellent aldimine-selectivity in the coexistence of aldehydes by means of dicyanoketene ethylene acetal (DCKEA) and the related polymer-supported dicyanoketene acetal as a recyclable π -acid catalyst.
HBF4 catalyzed Mannich-type reaction in aqueous media
Akiyama, Takahiko,Takaya, Jun,Kagoshima, Hirotaka
, p. 1045 - 1048 (2007/10/03)
HBF4 catalyzed Mannich-type reaction took place smoothly in aqueous media to afford β-amino carbonyl compounds in high yields. One-pot synthesis of β-amino carbonyl compounds from aldehyde and amine also worked well.
A catalytic amount of titanium tetrahalide as promoter for the addition reaction of silyl ketene acetals to imines
Shimizu, Makoto,Kume, Kouji,Fujisawa, Tamotsu
, p. 545 - 546 (2007/10/03)
In the presence of a catalytic amount of TiBr4 or Til4, the reaction of silyl ketene acetals with imines smoothly proceeds to give the corresponding β-amino esters in high yield with high anti-selectivity.
A Convenient Synthesis of β-Aminoesters. The Reaction of Imines with Ketene Silyl Acetals Catalyzed by Phosphonium Salts
Mukaiyama, Teruaki,Kashiwagi, Kouichi,Matsui, Shigekazu
, p. 1397 - 1400 (2007/10/02)
In the presence of a catalytic amount of a diphosphonium salt, the reaction of various imines, including 2--pyridine, with ketene silyl acetals proceeded smoothly to afford the corresponding β-aminoesters in good yields.
