1332835-67-2

Upstream product

• 13067-19-1 3,4-methylenedioxyacetanilide 
• 501-65-5 diphenyl acetylene 
• 14268-66-7 benzo[1,3]dioxolo-5-ylamine 
• 1000802-33-4 N-(6-iodobenzo[d][1,3]dioxol-5-yl)acetamide 

Relevant academic research and scientific papers

Mild and efficient synthesis of indoles and isoquinolones via a nickel-catalyzed Larock-type heteroannulation reaction

A simple and efficient approach for the preparation of substituted indoles and isoquinolones via a nickel-catalyzed Larock-type heteroannulation reaction is reported. This transformation employed air-stable and inexpensive Ni(dppp)Cl2 as a precatalyst and Et3N as a mild base. Moreover, the reaction occurs efficiently under mild conditions, and a wide range of substituted indoles and isoquinolones bearing various functional groups are obtained in moderate to excellent yields.

Synthesis of indoles via palladium-catalyzed C-H activation of N-aryl amides followed by coupling with alkynes

A convenient and efficient method for the construction of indole skeleton was developed via Pd-catalyzed C-H activation of N-aryl amides and subsequent coupling with alkynes. Both stoichiometric and catalytic versions have been successfully achieved.