Basic information

Product Name: 4-(8-Chloro-6,11-dihydro-11-hydroxy-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinecarboxylic Acid Ethyl Ester
Synonyms: 11-Hydroxy Dihydro Loratadine;4-(8-Chloro-6,11-dihydro-11-hydroxy-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinecarboxylic Acid Ethyl Ester;1-Piperidinecarboxylic acid, 4-(8-chloro-6,11-dihydro-11-hydroxy-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-, ethyl ester;Loratadine impurity A;Loratadine EP Impurity A ( USP RC F);8-Chloro-6,11-dihydro-11-[N-ethoxycarbonyl-4-piperidinyl]-11-hydroxy-5H-benzo[5,6] cyclohepta[1,2-b]pyridine
CAS NO:133284-74-9
Molecular Formula: C22H25ClN2O3
Molecular Weight: 400.8985
EINECS: N/A
Product Categories: Amines;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Amines, Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File: 133284-74-9.mol

Chemical Properties

Melting Point: N/A
Boiling Point: 545.1±50.0 °C(Predicted)
Flash Point: N/A
Appearance: /
Density: 1.294
Refractive Index: N/A
Storage Temp.: -20°C Freezer
Solubility: Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly), Ethanol (Slightly)
PKA: 12.23±0.20(Predicted)
CAS DataBase Reference: 4-(8-Chloro-6,11-dihydro-11-hydroxy-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinecarboxylic Acid Ethyl Ester(CAS DataBase Reference)
NIST Chemistry Reference: 4-(8-Chloro-6,11-dihydro-11-hydroxy-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinecarboxylic Acid Ethyl Ester(133284-74-9)
EPA Substance Registry System: 4-(8-Chloro-6,11-dihydro-11-hydroxy-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinecarboxylic Acid Ethyl Ester(133284-74-9)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 133284-74-9(Hazardous Substances Data)

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Usage
SDS
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133284-74-9 Usage

Uses

Used in Pharmaceutical Industry:
11-Hydroxy Dihydro Loratadine is used as an impurity in the production of Loratadine (L469575) for the following reasons:
Quality Control: The presence of 11-Hydroxy Dihydro Loratadine is monitored during the manufacturing process to ensure the quality and purity of the final product, Loratadine.
Regulatory Compliance: As an identified impurity, 11-Hydroxy Dihydro Loratadine is subject to regulatory guidelines that dictate its acceptable levels in the final drug product, ensuring patient safety and efficacy.
Research and Development: 11-Hydroxy Dihydro Loratadine may be utilized in research to understand the side effects or interactions that may occur due to its presence in Loratadine, potentially leading to improvements in the drug's formulation or administration methods.

Check Digit Verification of cas no

The CAS Registry Mumber 133284-74-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,2,8 and 4 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 133284-74:
(8*1)+(7*3)+(6*3)+(5*2)+(4*8)+(3*4)+(2*7)+(1*4)=119
119 % 10 = 9
So 133284-74-9 is a valid CAS Registry Number.

133284-74-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name	ethyl 4-(8-chloro-11-hydroxy-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-11-yl)piperidine-1-carboxylate

1.2 Other means of identification

Product number	-
Other names	4-(8-Chloro-6,11-dihydro-11-hydroxy-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinecarboxylic Acid Ethyl Ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:133284-74-9 SDS

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