1332841-01-6

Basic information

• Product Name: (2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol S-naproxen
• Synonyms: (2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol S-naproxen
• CAS NO: 1332841-01-6
• Molecular Weight: 481.632
• Mol File: 1332841-01-6.mol

Chemical Properties

• CAS DataBase Reference: (2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol S-naproxen(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol S-naproxen(1332841-01-6)
• EPA Substance Registry System: (2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol S-naproxen(1332841-01-6)

Safety Data

• Hazardous Substances Data: 1332841-01-6(Hazardous Substances Data)

Upstream product

• 175590-76-8 (2R,3R)/(2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol 
• 22204-53-1 (2S)-2-(6-methoxy(2-naphthyl))propanoic acid 

Downstream Products

• 454221-08-0 (-)-(2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methyl-pentan-3-ol 

Relevant articles and documents

IMPROVED RESOLUTION METHODS FOR ISOLATING DESIRED ENANTIOMERS OF TAPENTADOL INTERMEDIATES AND USE THEREOF FOR THE PREPARATION OF TAPENTADOL

Provided herein is an improved and industrially advantageous optical resolution method for resolving (2R,3R)/(2S,3S)-l-dimethylamino-3-(3-methoxyphenyl)-2- methylpentan-3-ol, and use thereof for the preparation of tapentadol or a pharmaceutically acceptable salt thereof. Provided further herein is an improved and industrially advantageous optical resolution method for resolving (2R,3R)/(2S,3S)-[3-(3-methoxyphenyl)-2- methylpentyl]-dimethylamine, and use thereof for the preparation of tapentadol or a pharmaceutically acceptable salt thereof. Disclosed also herein is an improved, commercially viable and industrially advantageous process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof in high yield and purity.