133286-16-5Relevant academic research and scientific papers
Photocatalytic Markovnikov-type addition and cyclization of terminal alkynes leading to 4-sulfonyl quinoline-2(1H)-ones
Zhai, Yu-Lin,Zhou, Hui,Liu, Qing-Quan,Leng, Bo-Rong,Zhang, Zixian,Li, Jia-Zhuo,Wang, De-Cai,Zhu, Yi-Long
supporting information, p. 5112 - 5115 (2022/04/21)
A new and expedient photocatalytic protocol for the construction of quinolin-2(1H)-ones via Markovnikov-type sulfonylation/6-endo-trig cyclization/selective C(O)-CF3 bond cleavage starting from N-alkyl-N-(2-ethynylphenyl)-2,2,2-trifluoroacetamides and sulfinic acids has been developed. It is as an unprecedented protocol for the preparation of 4-sulfonylquinoline-2(1H)-ones with high efficiency, mild reaction conditions, acceptable yields and a wide range of substrates.
