1332880-35-9Relevant academic research and scientific papers
Acylative desymmetrization of glycerol derivatives by chiral dmap derivatives
Ashihara, Kosuke,Mandai, Hiroki,Mitsudo, Koichi,Suga, Seiji
, p. 1083 - 1090 (2021/06/21)
An efficient enantioselective acylative desymmetrization of glycerol was developed by using a chiral DMAP derivatives 1e having a 1,1-binaphthyl unit. The reactions required only 0.1 mol% of the catalyst and showed moderate to good enantioselectivity (up
Desymmetrization of meso-glycerol derivatives induced by L -histidine-derived acylation catalysts
Sakakura, Akira,Umemura, Shuhei,Ishihara, Kazuaki
, p. 1938 - 1942 (2011/10/08)
The desymmetrization of meso-glycerol derivatives bearing a 3-pyrroline-1-carbonyl (Pyroc) directing group is demonstrated through an enantioselective acylation reaction promoted by L-histidine-derived bifunctional catalysts. The desired monoacylated products are obtained in good yields (up to 74%) with high enantioselectivities (up to 99% ee). Copyright
