133308-65-3

Upstream product

• 133308-74-4 2-Amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydrobenzoquinolizine-2-carbonitrile 
• 102-36-3 3,4-dichlorophenylisocyanate 

Downstream Products

• 136334-42-4 (+/-)-2R^*,11bS^*-3'-(3,4-Dichlorophenyl)-4'-imino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydrospiroquinolizin-2,5'-imidazolidin>-2'-one 
• 136334-61-7 (+/-)-2R^*,11bS^*-3'-(3,4-Dichlorophenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydrospiroquinolizin-2,5'-imidazolidine>-2',4'-dione hydrochloride 

Relevant academic research and scientific papers

Synthesis of 1'-Substituted and 1',3'-Disubstituted (+/-)-2R*,11bS*-9,10-Dimethoxy-1,3,4,6,7,11b-Hexahydrospiroquinolizin-2,5'-imidazolidine>-2',4'-diones

The results of the reaction between (+/-)-2R*,11bS*-2-alkyl(aryl)amino-1,3,4,6,7,11b-hexahydrobenzoquinolizine-2-carbonitriles 2 and isocyanates under a variety of experimental conditions are discussed.The ureides 3 and iminohydantoins 4 thus obtained were used to prepare N3-monosubstituted and N1,N3-disubstituted derivatives of the (+/-)-2R*,11bS*-9,10-dimethoxy-1,3,4,6,7,11b-hexahydrospiroquinolizin-2,5'-imidazolidine>-2',4'-dione system 1.The stereochemistry of these compounds is discussed, on the basis of spectroscopic evidence and study of their chemical reactivity.