136334-42-4Relevant articles and documents
Synthesis of 1'-Substituted and 1',3'-Disubstituted (+/-)-2R*,11bS*-9,10-Dimethoxy-1,3,4,6,7,11b-Hexahydrospiroquinolizin-2,5'-imidazolidine>-2',4'-diones
Menendez, J. Carlos,Soellhuber, Monica M.
, p. 923 - 932 (2007/10/02)
The results of the reaction between (+/-)-2R*,11bS*-2-alkyl(aryl)amino-1,3,4,6,7,11b-hexahydrobenzoquinolizine-2-carbonitriles 2 and isocyanates under a variety of experimental conditions are discussed.The ureides 3 and iminohydantoins 4 thus obtained were used to prepare N3-monosubstituted and N1,N3-disubstituted derivatives of the (+/-)-2R*,11bS*-9,10-dimethoxy-1,3,4,6,7,11b-hexahydrospiroquinolizin-2,5'-imidazolidine>-2',4'-dione system 1.The stereochemistry of these compounds is discussed, on the basis of spectroscopic evidence and study of their chemical reactivity.