1333159-34-4Relevant academic research and scientific papers
Copper-catalyzed oxidative trifluoromethylation of terminal alkenes using nucleophilic CF3SiMe3: Efficient C(sp3)-CF 3 bond formation
Chu, Lingling,Qing, Feng-Ling
supporting information; experimental part, p. 2106 - 2109 (2012/07/03)
An efficient C(sp3)-CF3 bond-forming reaction via Cu-catalyzed oxidative trifluoromethylation of terminal alkenes has been developed, which proceeds under mild conditions using readily available, less expensive CF3SiMe3 as the source of the CF3 group. This method allows access to a variety of trifluoromethylated allylic compounds.
Copper-catalyzed trifluoromethylation of terminal alkenes through allylic C-H bond activation
Xu, Jun,Fu, Yao,Luo, Dong-Fen,Jiang, Yuan-Ye,Xiao, Bin,Liu, Zhao-Jing,Gong, Tian-Jun,Liu, Lei
supporting information; experimental part, p. 15300 - 15303 (2011/11/11)
An unprecedented type of reaction for Cu-catalyzed trifluoromethylation of terminal alkenes is reported. This reaction represents a rare instance of catalytic trifluoromethylation through C(sp3)-H activation. It also provides a mechanistically unique example of Cu-catalyzed allylic C-H activation/functionalization. Both experimental and theoretical analyses indicate that the trifluoromethylation may occur via a Heck-like four-membered-ring transition state.
