1333159-57-1Relevant academic research and scientific papers
Iron-mediated Markovnikov-selective hydro-trifluoromethylthiolation of unactivated alkenes
Yang, Tao,Lu, Long,Shen, Qilong
, p. 5479 - 5481 (2015)
An iron-mediated hydro-trifluoromethylthiolation of unactivated olefins under mild conditions was described for the first time. The reaction occurred to full conversion within 30 min at 0 °C and tolerates a variety of functional groups. Preliminary mechan
Copper-catalyzed trifluoromethylation of terminal alkenes through allylic C-H bond activation
Xu, Jun,Fu, Yao,Luo, Dong-Fen,Jiang, Yuan-Ye,Xiao, Bin,Liu, Zhao-Jing,Gong, Tian-Jun,Liu, Lei
supporting information; experimental part, p. 15300 - 15303 (2011/11/11)
An unprecedented type of reaction for Cu-catalyzed trifluoromethylation of terminal alkenes is reported. This reaction represents a rare instance of catalytic trifluoromethylation through C(sp3)-H activation. It also provides a mechanistically unique example of Cu-catalyzed allylic C-H activation/functionalization. Both experimental and theoretical analyses indicate that the trifluoromethylation may occur via a Heck-like four-membered-ring transition state.
