1333159-68-4Relevant academic research and scientific papers
Synthesis of ten membered di-oxa-carbocyclic annulated flavones and olefin tethered bisflavone derivatives–olefin ring closing / cross metathesis
Balaiah, Neeradi,Hemasri, Yerrabelly,Rao, Yerrabelly Jayaprakash
, (2022/02/25)
A practical and efficient synthetic strategy to a series of unique ten membered dioxa carbocycle annulated 6-6-10-6 tetracyclic flavones (52-58%) and oxa-olefin bridged bisflavone/chromone derivatives (50-62%) has been developed in this scheme. 3-Hydroxyflavone and C-2 styryl/heteryl chromones were synthesized and utilized as scaffolds for oxacarbocycle annulations and homocouplings at pyran ring through olefin ring-closing and cross metathesis using Grubbs’ 2nd generation catalyst. The potential application of flavones and chromone derivatives in new drug discovery discriminates the importance of powerful synthetic pathways to obtain such diverse heterocyclic derivatives.
