1333229-48-3Relevant academic research and scientific papers
A novel and efficient route for the preparation of atorvastatin
Gao, Jian,Guo, Yang Hui,Wang, Ya Ping,Wang, Xiang Jing,Xiang, Wen Sheng
scheme or table, p. 1159 - 1162 (2012/01/16)
A novel and efficient synthetic method of atorvastatin was described. The key step of the synthesis was the construction of the olefin linkage between the chiral side chain and skeleton via a Horner-Wadsworth-Emmons reaction, resulting in the advanced intermediate of atorvastatin under hydrogenation of the olefin over Pd/C. This novel method is more useful for the practical synthesis of atorvastatin than its document reported methods.
