1333231-82-5

Basic information

• Product Name: 4-nitro-3-phenyl-5-m-tolylisoxazole
• Synonyms: 4-nitro-3-phenyl-5-m-tolylisoxazole
• CAS NO: 1333231-82-5
• Molecular Weight: 280.283
• Mol File: 1333231-82-5.mol

Chemical Properties

• CAS DataBase Reference: 4-nitro-3-phenyl-5-m-tolylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-nitro-3-phenyl-5-m-tolylisoxazole(1333231-82-5)
• EPA Substance Registry System: 4-nitro-3-phenyl-5-m-tolylisoxazole(1333231-82-5)

Safety Data

• Hazardous Substances Data: 1333231-82-5(Hazardous Substances Data)

Upstream product

• 61946-92-7 3-methyl-N-hydroxy-benzenecarboximidoyl chloride 
• 614-21-1 2-nitroacetophenone 

Relevant articles and documents

Trifluoromethylation of aromatic isoxazoles: Regio- and diastereoselective route to 5-trifluoromethyl-2-isoxazolines

It all adds up: The activation of aromatic isoxazoles with a nitro group at the 4-position has enabled the first regio- and diastereoselective trifluoromethylation at the 5-position of isoxazoles by nucleophilic addition using Me3SiCF3 (see scheme; DMF=N,N′- dimethylformamide). The process was demonstrated with a broad range of 3,5-aromatic, heteroaromatic and aliphatic substrates.