1333242-25-3Relevant academic research and scientific papers
The effect of sulfonate leaving groups on the hypoxia-selective toxicity of nitro analogs of the duocarmycins
Ashoorzadeh, Amir,Atwell, Graham J.,Pruijn, Frederik B.,Wilson, William R.,Tercel, Moana,Denny, William A.,Stevenson, Ralph J.
, p. 4851 - 4860 (2011/09/21)
A series of 3-substituted (5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl sulfonate (nitroCBI) prodrugs containing sulfonate leaving groups undergo hypoxia-selective metabolism to form potent DNA minor groove alkylating agents. They were evaluated (alon
