1333244-33-9Relevant academic research and scientific papers
Concise Cu (I) catalyzed synthesis of substituted benzofurans via a Tandem SNAr/C-O coupling process
Song, Zhiguo J.,Tan, Lushi,Liu, Guiquan,Ye, Honglin,Dong, Jianming
, p. 1088 - 1092 (2017/01/16)
A novel and convergent approach to tetrasubstituted benzofurans was developed from ortho-bromo aryl fluorides and keto-Amides via one-pot SNAr displacement and subsequent Cu(I) catalyzed C-O coupling on the ortho-bromide. The scope of this methodology was demonstrated on several similar substrates.
TETRACYCLIC HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
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Paragraph 0792, (2014/08/07)
The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
Facile functionalization at the C2 position of a highly substituted benzofuran
He, Shuwen,Li, Peng,Dai, Xing,McComas, Casey C.,Du, Chunyan,Wang, Ping,Lai, Zhong,Liu, Hong,Yin, Jingjun,Bulger, Paul G.,Dang, Qun,Xiao, Dong,Zorn, Nicolas,Peng, Xuanjia,Nargund, Ravi P.,Palani, Anandan
supporting information, p. 2212 - 2216 (2014/04/17)
To expedite an SAR study of the C2 position of a highly substituted benzofuran ring system, we developed a method for the preparation of a key precursor, iodide 10. From iodide 10, a diverse set of compounds with different substituents at the C2 position were prepared efficiently.
INHIBITORS OF HEPATITIS C VIRUS NS5B POLYMERASE
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, (2011/10/03)
Compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and /or viral production in a cell-based system. Wherein Z, R30, R40, R50 and R60 of compounds of formula (I) are herein defined as in the description.
