133329-83-6

Upstream product

• 133329-79-0 (2R,4S)-4-(tert-butyldimethylsilyl)oxymethyl-2-methyl-γ-butyrolactone 
• 76-83-5 trityl chloride 
• 62396-80-9 (5S)-(5-tert-butyldimethylsilyloxymethyl)furan-2(5H)-one 

Downstream Products

• 133329-84-7 (2S,4R)-2-Methoxy-4-methyl-5-trityloxy-pentanal 
• 133329-85-8 (1R,2S,4R)-2-Methoxy-4-methyl-1-(4-methyl-furan-2-yl)-5-trityloxy-pentan-1-ol 
• 133329-85-8 (1S,2S,4R)-2-Methoxy-4-methyl-1-(4-methyl-furan-2-yl)-5-trityloxy-pentan-1-ol 
• 133329-90-5 (2S,3S,5S,6R)-2,5-Dimethoxy-6-((1S,3R)-1-methoxy-3-methyl-4-trityloxy-butyl)-3-methyl-tetrahydro-pyran 
• 133329-90-5 (2S,3R,5S,6R)-2,5-Dimethoxy-6-((1S,3R)-1-methoxy-3-methyl-4-trityloxy-butyl)-3-methyl-tetrahydro-pyran 
• 133329-87-0 (2R,6S)-6-Methoxy-2-((1S,3R)-1-methoxy-3-methyl-4-trityloxy-butyl)-5-methyl-6H-pyran-3-one 
• 133329-89-2 (2R,3S,6S)-3,6-Dimethoxy-2-((1S,3R)-1-methoxy-3-methyl-4-trityloxy-butyl)-5-methyl-3,6-dihydro-2H-pyran 
• 133329-88-1 (2S,3S,6S)-6-Methoxy-2-((1S,3R)-1-methoxy-3-methyl-4-trityloxy-butyl)-5-methyl-3,6-dihydro-2H-pyran-3-ol 
• 133329-86-9 (2R,6S)-6-Hydroxy-2-((1S,3R)-1-methoxy-3-methyl-4-trityloxy-butyl)-5-methyl-6H-pyran-3-one 

Relevant academic research and scientific papers

An enantioselective synthesis of the C(10) to C(20) fragment of FK506

The synthesis of the C(10) to C(20) fragment 4 of FK506 from (4S)-4-[(tert-butyldimethylsilyl)-oxymethyl]-4-butanolide (9) is described. A key reaction is the chelation controlled addition of 2-lithio-4-methyl-furan (15b) to aldehyde 8.