An enantioselective synthesis of the C(10) to C(20) fragment of FK506

DOI: 10.1016/S0040-4039(00)71216-0

Source and publish data:

Tetrahedron Letters p. 53 - 56 (1991)

Update date:2022-09-26

Topics:

Authors:

Maier Maier

Schoffling

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Article abstract of DOI:10.1016/S0040-4039(00)71216-0

The synthesis of the C(10) to C(20) fragment 4 of FK506 from (4S)-4-[(tert-butyldimethylsilyl)-oxymethyl]-4-butanolide (9) is described. A key reaction is the chelation controlled addition of 2-lithio-4-methyl-furan (15b) to aldehyde 8.

Full text of DOI:10.1016/S0040-4039(00)71216-0

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