An enantioselective synthesis of the C(10) to C(20) fragment of FK506

DOI: 10.1016/S0040-4039(00)71216-0

Source and publish data:

Tetrahedron Letters p. 53 - 56 (1991)

Update date:2022-09-26

Topics:

Authors:

Maier Maier

Schoffling

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)71216-0

The synthesis of the C(10) to C(20) fragment 4 of FK506 from (4S)-4-[(tert-butyldimethylsilyl)-oxymethyl]-4-butanolide (9) is described. A key reaction is the chelation controlled addition of 2-lithio-4-methyl-furan (15b) to aldehyde 8.

Full text of DOI:10.1016/S0040-4039(00)71216-0

Products guided by the article

Product name:(2S,4R)-2-Methoxy-4-methyl-5-trityloxy-pentan-1-ol

Cas No:133329-83-6

R&D Labs maybe for 133329-83-6

Zhejiang Genebest Pharmaceutical Co.,Ltd.

Contact:0086-571-63532866

Address:No.1 Jinboshi Rd Lishan Town Fuyang City Zhejiang Province China
Xi'an yuanfar international trade company

website:https://www.yuanfarchemical.com

Contact:86-029-88745613 ext 828

Address:Floor19th ,B Building, Oak Block,No.36 South Fenghui Road, Dev. Zone of High-Tech Ind.,Xi’an, China
Shaanxi Sinuote Biotech Co.,Ltd

Contact:+86-29-68859685

Address:No 18,Taiyuan Road ,Xi'an city ,China
Zhejiang Golden-Shell Pharmaceutical Co.,Ltd.

Contact:+86-576-87501888 / 87501988

Address:No.89 Zhongxing Road. Li'ao, Yuhuan, Zhejiang, China
shanghai hekang chemical co.ltd

Contact:021-54173790

Address:328 WuHe Road, Building #A, 2nd Floor, Minhang, Shanghai 201109, China

Relevant to this article

Synthesis of two diastereomers of iriomoteolide-1a via a tunable four-module coupling approach using ring-closing metathesis as the key step

Doi:10.1055/s-0030-1260822
(2011)
Remote substitution on N-heterocyclic carbenes heightens the catalytic reactivity of their palladium complexes

Doi:10.1021/om200349y
(2011)
Tin(IV) porphyrin functionalization of electrochemically active fluoride-doped tin-oxide (FTO) via Huisgen [3+2] click chemistry

Doi:10.1142/S1088424611002970
(2011)
Total Synthesis of (?)-Pepluanol B: Conformational Control of the Eight-Membered-Ring System

Doi:10.1002/anie.201915876
(2020)
Synthesis and chemical characterisation of some new diheteroaryl thienothiophene derivatives

Doi:10.3390/molecules16097706
(2011)
SUBSTITUTED 2-METHYL- AND 2-METHYLENEINDOLINES. 3. NITROAMINO-5,6-DISUBSTITUTED 2-METHYL- AND 2-METHYLENEINDOLINES

Doi:10.1007/BF00476978
(1990)

Article Doi