133331-03-0

Basic information

• Product Name: 4-Isothiocyanato-N-(2-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethyl)-benzamide
• CAS NO: 133331-03-0
• Molecular Weight: 597.728
• Mol File: 133331-03-0.mol

Chemical Properties

• CAS DataBase Reference: 4-Isothiocyanato-N-(2-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethyl)-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Isothiocyanato-N-(2-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethyl)-benzamide(133331-03-0)
• EPA Substance Registry System: 4-Isothiocyanato-N-(2-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethyl)-benzamide(133331-03-0)

Safety Data

• Hazardous Substances Data: 133331-03-0(Hazardous Substances Data)

Upstream product

• 133342-69-5 4-Nitro-N-(2-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethyl)-benzamide 
• 122-04-3 4-nitro-benzoyl chloride 
• 133342-66-2 4-(3-(10-92-trifluoromethyl)phenothiazinyl)propyl-1-(2-aminoethyl)-piperazine hydrochloride 
• 463-71-8 thiophosgene 

Relevant articles and documents

Synthesis of some phenothiazine derivatives as potential affinity ligands for the central dopamine receptors

Syntheses of several phenothiazine ligands as potential affinity probes for the D1 and D2-dopamine receptors derived from 4-(3-(10-(2-trifluoromethyl) phenothiazinyl) propyl)-1-(2-aminoethyl)-piperazine hydrochloride are described and their interactions with D1- and D2-dopamine receptors of the bovine caudate nucleus have been characterized. The bromoacetylamido-, maleinimido-, and isothiocyanato-derivatives expressed low selectivity and moderate affinity for both categories of dopamine receptors. 4-(3-(10-(2-Trifluoromethyl) phenothiazinyl)propyl)-1-(2-(isothiocyanatobenzoyl)ethyl)-piperazine hydrochloride did not discriminate among the two subclasses of the dopamine receptors, but showed an extremely strong irreversible binding to the D1-receptors and thus is promising as a highly specific affinity ligand for biochemical and pharmacological studies of the D1-dopamine receptors.