1333316-46-3

Upstream product

• 58481-10-0 2-iodopyridine-4-carboxylic acid 
• 99931-82-5 1-(5-bromopyrimidin-2-yl)piperazine 
• 1333316-49-6 tert-butyl (2-{4-[5-(benzyloxy)pyrimidin-2-yl]piperazin-1-yl}-2-oxoethyl)carbamate 
• 100-51-6 benzyl alcohol 
• 87789-61-5 1-(5-Benzyloxy-2-pyrimidinyl)piperazine 

Downstream Products

• 1333320-40-3 [⁽¹⁸⁾F]-N-{2-[4-(5-benzyloxy-pyrimidin-2-yl)-piperazin-1-yl]-2-oxo-ethyl}-2-fluoropyridine-4-carboxamide 

Relevant academic research and scientific papers

SPECT IMAGING AGENTS OF AMYLOID PLAQUES

The invention relates to novel iodine -radiolabeled compounds useful for diagnosing Alzheimer's desease, to respective novel precursors for the synthesis of such compounds, and to the process of manufacturing said imaging agent of the following Formula (I), wherein Q is a six membered aromatic ring, either carbocycle or heterocycle with one N- atom, wherein X1, X2, X3, X4 and X5 are independently selected from N or C, and wherein zero or one of X1 ( X2, X3, X4 or X5 is N and the remaining ones are C; A is either Sn(alkyl)3, I, l-123, l-124, l-125, l-131, Br; wherein alkyl comprises methyl, ethyl, propyl, butyl, pentyl and hexyl, Y is C or N; with the proviso that if X1 ( X2, X3, X4 or X5 has the meaning of N, substitution by A in that position is excluded; or a pharmaceutically acceptable salt thereof.

A NOVEL PET IMAGING AGENT OF AMYLOID PLAQUES AND ITS PRECURSOR

The invention relates to a [18F]-labeled PET tracer for imaging of Alzheimer's Disease, a suitable precursor for that PET tracer, and the process for preparing the respective [18F]-labeled PET tracer of the fol lowing Formula, wherein X is selected from the group consisting of: F, CI, Br, I, 18F, F, leaving groups, such as nitro and trimethyl ammonium, or a pharmaceutically acceptable salt thereof.