1333341-46-0

Upstream product

• 1392272-40-0 C₈H₈FIN₂S 
• 1258884-52-4 2-fluoro-4-iodo-N-((methylimino)methylene)aniline 
• 162337-80-6 methyl 3-methoxycarbonylfuran-2-ylacetate 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 29632-74-4 2-fluro-4-iodoaniline 
• 50-00-0 formaldehyd 
• 1289572-17-3 methyl 6-(2-fluoro-4-iodophenylamino)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridine-7-carboxylate 
• 124-40-3 dimethyl amine 

Downstream Products

• 1289572-79-7 2-((dimethylamino)methyl)-6-(2-fluoro-4-iodophenylamino)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridine-7-carboxylic acid 

Relevant academic research and scientific papers

NOVEL 6-ARYLAMINO PYRIDONE CARBOXAMIDE AS MEK INHIBITORS

The invention provides novel substituted 6-arylamino pyridone carboxamides represented by Formula I, or a pharmaceutically acceptable salt, solvate, poly- morph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans.