1333377-65-3 Usage
Uses
Used in Anticancer Applications:
CHR-6494 is used as a small-molecule inhibitor of histone kinase haspin for its wide spectrum of anticancer effects. It has demonstrated the ability to cause mitotic catastrophe, upregulate BUB1 and cyclin B1 levels, and potently induce apoptosis in various cancer cell lines, including HeLa, HCT-116, and MDA-MB-231. Additionally, CHR-6494 has shown efficacy in blocking bFGF-induced sprouting vessels and suppressing tumor growth in a HCT-116 xenografted mouse model.
Used in Drug Development and Research:
CHR-6494 is used as a research tool for studying the role of haspin in mitosis and its potential as a therapeutic target in cancer. Its potent and selective inhibition of haspin activity makes it a valuable compound for investigating the underlying mechanisms of cell cycle regulation and the development of novel cancer treatments.
Used in Drug Delivery Systems:
While the provided materials do not specifically mention drug delivery systems for CHR-6494, it can be inferred that, similar to other small-molecule inhibitors, CHR-6494 could potentially be incorporated into various drug delivery systems to improve its bioavailability, targeting, and therapeutic outcomes in cancer treatment. These systems may include nanoparticles, liposomes, or other advanced drug delivery technologies to enhance the efficacy and safety of CHR-6494 in clinical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1333377-65-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,3,3,7 and 7 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1333377-65:
(9*1)+(8*3)+(7*3)+(6*3)+(5*3)+(4*7)+(3*7)+(2*6)+(1*5)=153
153 % 10 = 3
So 1333377-65-3 is a valid CAS Registry Number.
