1333393-77-3

Basic information

• Product Name: tert-butyl 3-(prop-2-ynyloxy)phenylcarbamate
• Synonyms: tert-butyl 3-(prop-2-ynyloxy)phenylcarbamate
• CAS NO: 1333393-77-3
• Molecular Weight: 247.294
• Mol File: 1333393-77-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl 3-(prop-2-ynyloxy)phenylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-(prop-2-ynyloxy)phenylcarbamate(1333393-77-3)
• EPA Substance Registry System: tert-butyl 3-(prop-2-ynyloxy)phenylcarbamate(1333393-77-3)

Safety Data

• Hazardous Substances Data: 1333393-77-3(Hazardous Substances Data)

Upstream product

• 591-27-5 m-Hydroxyaniline 
• 19962-06-2 tert-butyl 3-hydroxyphenylcarbamate 
• 106-96-7 propargyl bromide 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1333393-98-8 C₂₅H₂₀ClN₅O₃S₂ 
• 1333393-99-9 C₂₆H₂₂ClN₅O₃S 
• 1333394-00-5 C₂₂H₁₈BrClN₄O₃S₂ 
• 1333394-01-6 C₂₄H₂₁ClN₄O₃S 
• 1333394-02-7 C₂₃H₂₁ClN₄O₃S₂ 
• 1333394-03-8 C₂₄H₂₀Cl₂N₄O₃S 
• 1333394-07-2 C₂₃H₂₀ClN₅O₃S 
• 60042-20-8 (3-prop-2-ynoxyphenyl)ammonium chloride 
• 1333393-91-1 (E)-N-(3-((1-(benzo[b]thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-2-(3-chlorophenyl)ethenesulfonamide 
• 1333393-85-3 C₁₅H₁₅N₅O 
• 1333393-84-2 3-((1-(benzo[b]thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)aniline 
• 1333393-83-1 C₁₇H₁₅N₅OS 
• 1333393-82-0 C₁₈H₁₇N₅O 
• 1333393-81-9 C₁₅H₁₆N₄OS 

Relevant articles and documents

Antibody-medicine conjugate targeting EGFR and preparation method and application thereof

The invention relates to an antibody-medicine conjugate targeting an EGFR. The antibody-medicine conjugate targeting the EGFR is characterized in that the antibody-medicine conjugate of a structure shown in a formula I or pharmaceutically-accepted salt or solvate is involved. According to a structural formula of the antibody-medicine conjugate targeting the EGFR, n represents the medicine-antibody proportion and is 3-5; R is O or CONH or NHCO; R is in para-position or meta-position; p is 1-6; m is 0-20. According to the antibody-medicine conjugate targeting the EGFR, based on a bis-ethylene sulfamide connection connexin technology, the antibody-medicine conjugate targeting the EGFR is synthesized for the first time. According to the antibody-medicine conjugate targeting the EGFR, internal sulphur-sulphur bonds of an antibody are broken and then bridged, the conjugate with good uniformity and DAR of about 4 can be obtained, and the antibody is wide in application range.