1333393-98-8

Basic information

• Product Name: C₂₅H₂₀ClN₅O₃S₂
• Synonyms: C₂₅H₂₀ClN₅O₃S₂
• CAS NO: 1333393-98-8
• Molecular Weight: 538.051
• Mol File: 1333393-98-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₀ClN₅O₃S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₀ClN₅O₃S₂(1333393-98-8)
• EPA Substance Registry System: C₂₅H₂₀ClN₅O₃S₂(1333393-98-8)

Safety Data

• Hazardous Substances Data: 1333393-98-8(Hazardous Substances Data)

Upstream product

• 591-27-5 m-Hydroxyaniline 
• 19962-06-2 tert-butyl 3-hydroxyphenylcarbamate 
• 2039-85-2 3-Chlorostyrene 
• 1333393-83-1 C₁₇H₁₅N₅OS 
• 216955-76-9 (E)-2-(3’ chlorophenyl)ethene-1-sulfonyl chloride 
• 1333394-22-1 C₂₂H₂₃N₅O₃S 
• 1333393-77-3 tert-butyl 3-(prop-2-ynyloxy)phenylcarbamate 
• 37859-42-0 1,3-benzothiazol-2-ylmethanol 

Relevant articles and documents

Synthesis and biochemical evaluation of triazole/tetrazole-containing sulfonamides against thrombin and related serine proteases

A small library of 25 triazole/tetrazole-based sulfonamides have been synthesized and further evaluated for their inhibitory activity against thrombin, trypsin, tryptase and chymase. In general, the triazole-based sulfonamides inhibited thrombin more efficiently than the tetrazole counterparts. Particularly, compound 26 showed strong thrombin inhibition (Ki = 880 nM) and significant selectivity against other human related serine proteases like trypsin (Ki = 729 μM). Thrombin binding affinity of the same compound was determined by ITC and demonstrated that the binding of this new triazole-based scaffold is enthalpically driven, making it a good candidate for further development.