1333425-31-2

Upstream product

• 1333426-93-9 (S)-N-((S)-1-cyclohexylprop-2-yn-1-yl)-tert-butylsulfinamide 
• 1333426-91-7 (S)-N-((S)-1-cyclohexyl-3-(trimethylsilyl)prop-2-yn-1-yl)-tert-butylsulfinamide 
• 2043-61-0 cyclohexanecarbaldehyde 
• 1333428-08-2 C₁₈H₂₇N₅O₂ 
• 1333428-07-1 C₁₈H₂₉N₅O₃ 
• 1333428-03-7 C₁₇H₂₉N₅O₂S 

Downstream Products

• 1333426-25-7 furan-3-carboxylic acid {(S)-[1-(1-cyano-cyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-amide 
• 1333426-28-0 oxazole-5-carboxylic acid {(S)-[1-(1-cyano-cyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-amide 
• 1414873-67-8 C₂₄H₂₅N₅OS 
• 1333426-15-5 N-{(S)-[1-(1-cyanocyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-benzamide 
• 1333426-37-1 N-{(S)-[1-(1-cyano-cyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-nicotinamide 
• 1333426-53-1 4-cyano-N-{(S)-[1-(1-cyano-cyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-benzamide 
• 1333426-74-6 N-{(S)-[1-(1-cyano-cyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-4-(cyclopropanecarbonyl-amino)-benzamide 
• 1333426-20-2 4-acetylamino-N-{(S)-[1-(1-cyano-cyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-benzamide 
• 1333426-76-8 N-{(S)-[1-(1-cyano-cyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-4-methanesulfonylamino-benzamide 
• 1333426-66-6 N-{(S)-[1-(1-cyano-cyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-terephthalamide 
• 1333428-27-5 C₁₈H₂₈N₆O₃ 
• 1333425-33-4 morpholine-4-carboxylic acid {(S)-[1-(1-cyano-cyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-amide 
• 1333425-64-1 thiophene-3-carboxylic acid {(S)-[1-(1-cyano-cyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-amide 

Relevant academic research and scientific papers

Exploration of cathepsin S inhibitors characterized by a triazole P1-P2 amide replacement

This paper details exploration of a class of triazole-based cathepsin S inhibitors originally reported by Ellman and co-workers. SAR studies involving modifications across the whole inhibitor provide a perspective on the strengths and weaknesses of this class of inhibitors. In addition, we put the unique characteristics of this class of compounds into perspective with other classes of cathepsin S inhibitors.