1333428-08-2

Upstream product

• 1333465-63-6 C₁₃H₂₁N₅O 
• 1333428-04-8 C₁₃H₂₁N₅O*ClH 
• 1333428-07-1 C₁₈H₂₉N₅O₃ 
• 1333428-03-7 C₁₇H₂₉N₅O₂S 
• 1333426-93-9 (S)-N-((S)-1-cyclohexylprop-2-yn-1-yl)-tert-butylsulfinamide 
• 1333426-91-7 (S)-N-((S)-1-cyclohexyl-3-(trimethylsilyl)prop-2-yn-1-yl)-tert-butylsulfinamide 
• 2043-61-0 cyclohexanecarbaldehyde 

Downstream Products

• 1333425-33-4 morpholine-4-carboxylic acid {(S)-[1-(1-cyano-cyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-amide 
• 1333428-27-5 C₁₈H₂₈N₆O₃ 
• 1333425-31-2 1-[4-((S)-amino-cyclohexyl-methyl)-[1,2,3]triazol-1-yl]-cyclopropanecarbonitrile 
• 1333425-64-1 thiophene-3-carboxylic acid {(S)-[1-(1-cyano-cyclopropyl)-1H-[1,2,3]triazol-4-yl]-cyclohexyl-methyl}-amide 
• 1333428-43-5 1-[4-((S)-amino-cyclohexyl-methyl)-[1,2,3]triazol-1-yl]-cyclopropanecarbonitrile hydrochloride 

Relevant academic research and scientific papers

Exploration of cathepsin S inhibitors characterized by a triazole P1-P2 amide replacement

This paper details exploration of a class of triazole-based cathepsin S inhibitors originally reported by Ellman and co-workers. SAR studies involving modifications across the whole inhibitor provide a perspective on the strengths and weaknesses of this class of inhibitors. In addition, we put the unique characteristics of this class of compounds into perspective with other classes of cathepsin S inhibitors.

HETEROARYL NITRILE COMPOUNDS USEFUL AS INHIBITORS OF CATHEPSIN-S

Disclosed are Cathepsin-S reversible inhibitor compounds of the formula (I) which are useful in the treatment of autoimmune and other diseases. Also disclosed are pharmaceutical compositions containing the same, and methods of making and using the same.