1333470-29-3Relevant academic research and scientific papers
Consecutive three-component synthesis of (hetero)arylated propargyl amides by chemoenzymatic aminolysis-Sonogashira coupling sequence
Hassan, Sidra,Ullrich, Anja,Müller, Thomas J. J.
supporting information, p. 1571 - 1576 (2015/01/30)
A novel chemoenzymatic three-component synthesis of (hetero)arylated propargyl amides in good yields based upon Novozyme 435 (Candida antarctica lipase B (CAL-B)) catalyzed aminolysis of methyl carboxylates followed by Sonogashira coupling with (hetero)aryliodides in a consecutive one-pot fashion has been presented. This efficient methodology can be readily concatenated with a CuAAC (Cu catalyzed alkyne azide cycloaddition) as a third consecutive step to furnish 1,4-disubstituted 1,2,3-triazole ligated arylated propargyl amides. This one-pot process can be regarded as a transition metal catalyzed sequence that takes advantage of the copper source still present from the cross-coupling step.
Gold-catalyzed cyclization of nonterminal propargylic amides to substituted alkylideneoxazolines and-oxazines
Hashmi, A. Stephen K.,Schuster, Andreas M.,Schmuck, Martin,Rominger, Frank
supporting information; experimental part, p. 4595 - 4602 (2011/10/03)
The substrate scope of the gold-catalyzed cyclization of nonterminal propargylic amides to oxazolines and oxazines was investigated. Sixteen alkyl-substituted and 35 aryl-substited substrates were prepared by a very variable route from trimethylsilyl-(TMS
