174271-37-5

Upstream product

• 103-80-0 phenylacetyl chloride 
• 2450-71-7 Propargylamine 
• 1189342-28-6 2-phenyl-N-[3-(triisopropylsilyl)prop-2-ynyl]acetamide 
• 1189342-29-7 2-phenyl-N-[3-(tert-butyl(diphenyl)silyl)prop-2-ynyl]acetamide 
• 1189342-30-0 2-phenyl-N-[3-(tert-butyl(dimethyl)silyl)prop-2-ynyl]acetamide 
• 1189342-31-1 2-phenyl-N-[3-(triethylsilyl)prop-2-ynyl]acetamide 
• 1189342-32-2 2-phenyl-N-[3-(trimethylsilyl)prop-2-ynyl]acetamide 
• 53607-34-4 (2-bromo-2-nitroethyl)benzene 
• 101-41-7 benzeneacetic acid methyl ester 
• 2700-22-3 Benzylidenemalononitrile 
• 100-52-7 benzaldehyde 
• 1867-37-4 Benzylmalononitrile 
• 536-74-3 phenylacetylene 
• 103-82-2 phenylacetic acid 

Downstream Products

• 13654-20-1 2-phenyl-penta-2,4-dienenitrile 
• 1033037-42-1 2-benzyl-oxazole-5-carbaldehyde 
• 1189342-32-2 2-phenyl-N-[3-(trimethylsilyl)prop-2-ynyl]acetamide 
• 1214922-10-7 2-benzyl-5-(iodomethyl)oxazole 
• 1214921-89-7 2-benzyl-5-methylene-4,5-dihydrooxazole 
• 39856-59-2 2-benzyl-5-methyloxazole 
• 1311414-36-4 2-Phenyl-N-(3-(5-(3'-O-acetyl-2'-deoxyuridine))prop-2-ynyl)acetamide 
• 1311414-30-8 2-Phenyl-N-(3-(5-(2'-deoxyuridine))prop-2-ynyl)acetamide 
• 1334237-53-4 N-(5-bromo-2-methyl-1H-indol-3-yl)-2-(phenylacetamide) 
• 1381778-22-8 1-((2-benzyloxazol-5-yl)methyl)-4-phenyl-1,2,4-triazolidine-3,5-dione 
• 1381778-13-7 di-tert-butyl 1-((2-benzyloxazol-5-yl)methyl)hydrazine-1,2-dicarboxylate 
• 1381778-12-6 diisopropyl 1-((2-benzyloxazol-5-yl)methyl)hydrazine-1,2-dicarboxylate 
• 1381778-14-8 dibenzyl 1-((2-benzyloxazol-5-yl)methyl)hydrazine-1,2-dicarboxylate 
• 1381778-11-5 diethyl 1-((2-benzyloxazol-5-yl)methyl)hydrazine-1,2-dicarboxylate 

Relevant academic research and scientific papers

Synthesis of acyclic nucleoside phosphonates targeting flavin-dependent thymidylate synthase in Mycobacterium tuberculosis

Flavin-Dependent Thymidylate Synthase (FDTS) encoded by ThyX gene was discovered as a new class of thymidylate synthase involved in the de novo synthesis of dTMP named only in 30 % of human pathogenic bacteria. This target was pursed for the development of new antibacterial agents against multiresistant pathogens. We have developed a new class of ANPs based on the mimic of two natural's cofactors (dUMP and FAD) as inhibitors against Mycobacterium tuberculosis ThyX. Several synthetic efforts were performed to optimize regioselective N1-alkylation, cross-coupling metathesis and Sonogashira cross-coupling. Compound 19c showed a poor 31.8% inhibitory effect on ThyX at 200 μM.

COMPOUNDS FOR USE IN THE TREATMENT OF LIVER DISEASE

Bile acid derivatives, methods of manufacture thereof, and uses thereof are disclosed herein. The bile acid derivatives have demonstrated potential as therapeutics for treating liver disease.

InCl3-catalyzed 5- exo-dig cyclization/1,6-conjugate addition of N -propargylamides with p -QMs to construct oxazole derivatives

An InCl3-catalyzed atom-economic intramolecular 5-exo-dig cyclization/1,6-conjugate addition/aromatization of N-propargylamides with p-QMs to produce oxazoles tethering diarylmethane has been successfully developed. InCl3 not only se

Zn(OTf)2-catalyzed, microwave-promoted synthesis of 2-substituted 5-methyloxazoles from propargylic amides

The versatile conversion of propargylic amides to the respective 2-substituted 5-methyloxazoles was efficiently catalyzed by Zn(OTf)2 (5 mol%) under microwave irradiation in toluene. The method was applicable to a wide range of aliphatic, aroma

Ruthenium-Catalyzed Oxidative Amidation of Alkynes to Amides

Complex CpRuCl(PPh3)2 catalyzes reactions of terminal alkynes with 4-picoline N-oxide and primary and secondary amines to afford the corresponding amides. The reactions occur in chlorinated solvent and aqueous medium, showing applications in peptide chemistry. Stoichiometric studies reveal that the true catalysts of the processes are the vinylidene cations [CpRu(=C=CHR)(PPh3)2]+ which are oxidized to the Ru(η2-CO)-ketenes by the N-oxide. Finally, nucleophilic additions of primary and secondary amines to the free ketenes yield the corresponding amides.

Conjugation of a 5-nitrofuran-2-oyl moiety to aminoalkylimidazoles produces non-toxic nitrofurans that are efficacious in vitro and in vivo against multidrug-resistant Mycobacterium tuberculosis

Within the general nitrofuran carboxamide chemotype, chimera derivatives incorporating diversely substituted imidazoles attached via an alkylamino linker were synthesized. Antimycobacterial evaluation against drug-sensitive M. tuberculosis H37Rv strain id

Synthesis of gibberellic acid derivatives and their effects on plant growth

A series of novel C-3-OH substituted gibberellin derivatives bearing an amide group were designed and synthesized from the natural product gibberellic acid (GA3). Their activities on the plant growth regulation of rice and Arabidopsis were evaluated in vivo. Among these compounds, 10d and 10f exhibited appreciable inhibitory activities on rice (48.6% at 100 μmol/L) and Arabidopsis (41.4% at 100mol/L), respectively. These results provide new insights into the design and synthesis of potential plant growth regulators.

Sterically Demanding Oxidative Amidation of α-Substituted Malononitriles with Amines Using O2

An efficient amidation method between readily available 1,1-dicyanoalkanes and either chiral or nonchiral amines was realized simply with molecular oxygen and a carbonate base. This oxidative protocol can be applied to both sterically and electronically challenging substrates in a highly chemoselective, practical, and rapid manner. The use of cyclopropyl and thioether substrates support the radical formation of α-peroxy malononitrile species, which can cyclize to dioxiranes that can monooxygenate malononitrile α-carbanions to afford activated acyl cyanides capable of reacting with amine nucleophiles.

FeBr3-Catalyzed Tandem Reaction of N -Propargylamides with Disulfides or Diselenides for the Synthesis of Oxazole Derivatives

A methodology of FeBr3-catalyzed tandem reaction of N-propargylamides with disulfides or diselenides for the formation of oxazole derivatives has been developed. The strategy includes several steps in one pot. Series of N-propargylamides and disulfides were suitable as substrates in this transformation for synthesizing the corresponding oxazole derivatives in moderate to good yields.

Zn-catalyzed hydrohydrazination of propargylamides with BocNHNH2: A novel entry into the 1,2,4-triazine core

Hydrohydrazination of a variety of propargylamides with BocNHNH2 under Zn(OTf)2 catalysis, unexpectedly, gave dihydro-1,2,4-triazines with a loss of the protecting group. The initial products can be efficiently aromatized in situ wit