1333473-70-3

Upstream product

• 459870-95-2 3-(tert-butyl-dimethyl-silanyloxy)-pentanedial 
• 112904-68-4 3-(tert-butyl-dimethyl-silanyloxy)-pentanedioic acid dimethyl ester 
• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 7250-55-7 dimethyl 3-hydroxypentanedioate 
• 1333473-57-6 2-[(2R,4R,6R)-2-(4-methoxyphenyl)-6-{[(2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]methyl}-1,3-dioxan-4-yl]acetaldehyde 
• 1333473-56-5 2-[(2S,4S,6S)-2-(4-methoxyphenyl)-6-{[(2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]methyl}-1,3-dioxan-4-yl]ethanol 
• 1333473-55-4 1,3-bis[(2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]propan-2-ol 
• 1333473-54-3 {1,3-bis[(2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]propan-2-yloxy}(tert-butyl)dimethylsilane 
• 1333473-53-2 (3S,7S)-5-(tert-butyldimethylsilyloxy)nonane-1,3,7,9-tetraol 
• 1333473-52-1 (3R,7R)-1,9-bis[(S)-4-tert-butyl-2-thioxothiazolidin-3-yl]-5-(tertbutyldimethylsilyloxy)-3,7-dihydroxynonane-1,9-dione 
• 1333473-58-7 (2R,3R)-[(1R,2S)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl]-3-hydroxy-4-[(2S,4S,6R)-2-(4-methoxyphenyl)-6-{[(2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]methyl}-1,3-dioxan-4-yl]-2-methylbutanoate 

Downstream Products

• 1333473-60-1 (4S,5S,6R)-6-(tert-butyldimethylsilyloxy)-7-[(2R,4R,6R)-2-(4-methoxyphenyl)-6-{[ (2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]methyl}-1,3-dioxan-4-yl]-5-methylhept-1-en-4-ol 
• 1333473-62-3 (R)-4-[(2R,4R,6R)-6-{[(4R,5S,6S)-6-allyl-2,2,5-trimethyl-1,3-dioxan-4-yl]-methyl}-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-3-(4-methoxybenzyloxy)-butanal 
• 1333473-63-4 (4S,6S)-7-[ (2R,4R,6R)-6-{[(4R,5S,6S)-6-allyl-2,2,5-trimethyl-1,3-dioxan-4-yl]methyl}-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-4-hydroxy-1-{(4S,6R)-6-[ (3S,4S,E)-4-hydroxy-3,5-dimethylhex-1-enyl]-2,2-dimethyl-1,3-dioxan-4-yl}-6-(4-methoxybenzyloxy)heptan-2-one 
• 1333473-64-5 (3S,4S,E)-6-[(4R,6R)-6-{[(4R,6S)-6-{(R)-3-[(2R,4R,6R)-6-{[(4R,5S,6S)-6-allyl-2,2,5-trimethyl-1,3-dioxan-4-yl]methyl}-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-2-(4-methoxybenzyloxy)propyl}-2,2-dimethyl-1,3-dioxan-4-yl]methyl}-2,2-dimethyl-1,3-dioxan-4-yl]-2,4-dimethylhex-5-en-3-ol 
• 1333473-59-8 C₃₇H₅₄O₈Si 
• 1333473-72-5 C₃₄H₄₈O₈ 
• 1354728-55-4 C₅₁H₇₈O₁₂ 
• 1333473-71-4 C₃₆H₅₅NO₉Si 

Relevant academic research and scientific papers

Total synthesis of dermostatin A

The concise total synthesis of dermostatin A is described. Highlights include a two-directional application of the asymmetric acetate aldol method developed in our lab, a novel diastereotopic-group-selective acetal isomerization for terminus differentiation, and a selective cross-metathesis reaction between a terminal olefin and a trienal. A study of the scope and viability of similar cross-metathesis reactions is also described. The synthesis is convergent and utilizes fragments of roughly equal complexity.