1333473-63-4

Upstream product

• 1333473-72-5 C₃₄H₄₈O₈ 
• 1333473-59-8 C₃₇H₅₄O₈Si 
• 1333473-71-4 C₃₆H₅₅NO₉Si 
• 1333473-70-3 C₅₉H₇₇NO₁₁SSi 
• 1333473-61-2 (4S,5S,6R)-4-allyl-6-{[(2R,4R,6R)-2-(4-methoxyphenyl)-6-{[(2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]methyl}-1,3-dioxan-4-yl]methyl}-2,2,5-trimethyl-1,3-dioxane 
• 1333473-60-1 (4S,5S,6R)-6-(tert-butyldimethylsilyloxy)-7-[(2R,4R,6R)-2-(4-methoxyphenyl)-6-{[ (2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]methyl}-1,3-dioxan-4-yl]-5-methylhept-1-en-4-ol 
• 1333473-58-7 (2R,3R)-[(1R,2S)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl]-3-hydroxy-4-[(2S,4S,6R)-2-(4-methoxyphenyl)-6-{[(2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]methyl}-1,3-dioxan-4-yl]-2-methylbutanoate 
• 1333473-62-3 (R)-4-[(2R,4R,6R)-6-{[(4R,5S,6S)-6-allyl-2,2,5-trimethyl-1,3-dioxan-4-yl]-methyl}-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-3-(4-methoxybenzyloxy)-butanal 

Downstream Products

• 1333473-64-5 (3S,4S,E)-6-[(4R,6R)-6-{[(4R,6S)-6-{(R)-3-[(2R,4R,6R)-6-{[(4R,5S,6S)-6-allyl-2,2,5-trimethyl-1,3-dioxan-4-yl]methyl}-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-2-(4-methoxybenzyloxy)propyl}-2,2-dimethyl-1,3-dioxan-4-yl]methyl}-2,2-dimethyl-1,3-dioxan-4-yl]-2,4-dimethylhex-5-en-3-ol 
• 1354728-55-4 C₅₁H₇₈O₁₂ 

Relevant academic research and scientific papers

Total synthesis of dermostatin A

The concise total synthesis of dermostatin A is described. Highlights include a two-directional application of the asymmetric acetate aldol method developed in our lab, a novel diastereotopic-group-selective acetal isomerization for terminus differentiation, and a selective cross-metathesis reaction between a terminal olefin and a trienal. A study of the scope and viability of similar cross-metathesis reactions is also described. The synthesis is convergent and utilizes fragments of roughly equal complexity.