1333473-75-8Relevant academic research and scientific papers
Total synthesis of dermostatin A
Zhang, Yingchao,Arpin, Carolynn C.,Cullen, Aaron J.,Mitton-Fry, Mark J.,Sammakia, Tarek
experimental part, p. 7641 - 7653 (2011/12/14)
The concise total synthesis of dermostatin A is described. Highlights include a two-directional application of the asymmetric acetate aldol method developed in our lab, a novel diastereotopic-group-selective acetal isomerization for terminus differentiation, and a selective cross-metathesis reaction between a terminal olefin and a trienal. A study of the scope and viability of similar cross-metathesis reactions is also described. The synthesis is convergent and utilizes fragments of roughly equal complexity.
