133348-05-7Relevant articles and documents
Organometal-Free Arylation and Arylation/Trifluoroacetylation of Quinolines by Their Reaction with CF3-ynones and Base-Induced Rearrangement
Muzalevskiy, Vasiliy M.,Belyaeva, Kseniya V.,Trofimov, Boris A.,Nenajdenko, Valentine G.
, p. 9993 - 10006 (2020/09/09)
The reaction of quinolines with CF3-ynones resulted in the formation of 1,3-oxazinoquinolines. Subsequent treatment of the reaction mixture with a base initiated deep structural transformation of primary products. Both steps proceed in very high yield. As a result, unusual rearrangement of 1,3-oxazinoquinolines to form either 2-arylquinolines or 2-aryl-3-trifluoroacetylquinolines was discovered. The decisive role of the base in the reaction direction was shown. Using these reactions, highly efficient pathways to 2-arylquinolines and 2-aryl-3-trifluoroacetylquinolines were elaborated to provide the corresponding compounds in high yields using a simple one-pot procedure. The possible mechanism of rearrangement is discussed.
Phenyl dihydroisoquinolines TRPV1 antagonists and its preparation method and application (by machine translation)
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Paragraph 0101; 0102; 0103, (2018/04/03)
The invention relates to the general formula (I) compounds and salts thereof, such compounds have a strong analgesic effect, part of the compound activity is far higher than the cinchophen and BCTC, and almost no hepatotoxins, gastric mucosa injury and body temperature rise side effect, the invention also relates to the preparation method of the compound and pharmaceutical preparations containing them. The invention synthesizes a series of general formula (I) compound and its pharmaceutically acceptable salt. (by machine translation)
