13335-50-7

Upstream product

• 2785-87-7 2-methoxy-4-n-propylphenol 
• 100-44-7 benzyl chloride 
• 57371-42-3 4-allyl-1-benzyloxy-2-methoxybenzene 
• 120-11-6 2-methoxy-1-(phenylmethoxy)-4-(1-propenyl)-benzene 

Downstream Products

• 2785-87-7 2-methoxy-4-n-propylphenol 

Relevant academic research and scientific papers

Generation of Hydrogen from Water: A Pd-Catalyzed Reduction of Water Using Diboron Reagent at Ambient Conditions

Production of hydrogen from renewable sources, particularly from water, is an intensive area of research, which has far-reaching relevance in hydrogen economy. A homogeneous catalytic method is presented for producing clean hydrogen gas from water, in a reaction of water with a diboron compound as the reductant, under ambient reaction conditions. The Pd-catalytic system is stable in water and displays excellent recyclability. Hydroxy analogues such as alcohols are compatible with the Pd/B2Pin2 system and generate hydrogen gas efficiently. The B2Pin2-H2O system, in the presence of palladium, is an excellent catalytic system for selective hydrogenation of olefins.

Chemoselective hydrogenation catalyzed by Pd on spherical carbon

We have developed a highly chemoselective hydrogenation method using a novel palladium catalyst supported on spherical carbon (0.5 % Pd/SC). The 0.5 % Pd/SC exhibited a novel catalytic activity and could achieve the chemoselective hydrogenation of alkynes, alkenes, azides, nitro groups, and aliphatic O-tert-butyldimethylsilyl (TBS) ethers without hydrogenolysis of benzyl esters, benzyl ethers, nitriles, aromatic ketones, N-carbobenzyloxy (N-Cbz) protective groups, and aromatic O-TBS ethers. Highly selective spheres: The chemoselective hydrogenation of C-C multiple bonds, azides, nitro groups, and aliphatic O-tert-butyldimethylsilyl (TBS) ethers is achieved in the presence of benzyl esters, benzyl ethers, nitriles, aromatic ketones, N-carbobenzyloxy (Cbz) protective groups, and aromatic O-TBS ethers by a novel heterogeneous palladium catalyst supported on spherical carbon (0.5 % Pd/SC). Copyright

Development of a palladium on boron nitride catalyst and its application to the semihydrogenation of alkynes

The simple preparative method for a novel palladium supported on boron nitride catalyst (Pd/BN) was accomplished. Pd/BN is widely applicable for the semihydrogenation of mono- as well as disubstituted alkynes to furnish the corresponding alkenes in the presence of diethylenetriamine (DETA), which exhibits both an unprecedented acceleration effect toward the semihydrogenation and a suppression effect with regard to the overhydrogenation to alkanes. Copyright

Chemoselective hydrogenation using molecular sieves-supported Pd catalysts: Pd/MS3A and Pd/MS5A

Palladium catalysts embedded on molecular sieves (MS3A and MS5A) were prepared by the adsorption of Pd(OAc)2 onto molecular sieves with its in situ reduction to Pd0 by MeOH as a reducing agent and solvent. 0.5% Pd/MS3A and 0.5% Pd/MS5A catalyzed the hydrogenation of alkynes, alkenes, and azides with a variety of coexisting reducible functionalities, such as nitro group, intact. It is noteworthy that terminal alkenes of styrene derivatives possessing electron-donating functionalities on the benzene nucleus were never hydrogenated under 0.5% Pd/MS5A-catalyzed conditions, while internal alkenes of 1-propenylbenzene derivatives were readily reduced to the corresponding alkanes.

Development of molecular sieves-supported palladium catalyst and chemoselective hydrogenation of unsaturated bonds in the presence of nitro groups

The chemoselective hydrogenation of unsaturated bonds and azide functionalities is achieved in the presence of nitro groups by a heterogeneous palladium catalyst supported on molecular sieves (MS3A). The present method shows a widerange of applicability with regard to substrates and the catalyst can be easily prepared and reused at least three times without any loss of activity.

Squaric acid derivatives prevent the removal of N-Cbz and N-Fmoc groups under catalytic hydrogenation reaction

Under the catalytic hydrogenation conditions (H2/Pd-C), squaric acid derivatives 4 and 7 were found to be effective additives for chemoselective reduction of olefins and an alkyne having an N-Cbz or N-Fmoc group where the amino group remained to be protected. Benzyl esters having an N-Cbz or N-Fmoc group we re also selectively removed to give the corresponding N-protected carboxylic acids.

Hypolipidemic analogues of ethyl 4 benzyloxybenzoate

A series of compounds related to ethyl 4-benzyloxybenzoate was synthesized and evaluated for potential hypolipidemic activity in rats. Structure-activity relationships are discussed in terms of cholesterol-lowering activity together with effects on body weight gain and liver lipids. A number of the compounds inhibited cholesterol and free fatty acid biosynthesis from [1-14C]acetate in rat liver slices in vitro. Ethyl 4-benzyloxybenzoate, ethyl 4-benzyloxybenzoic acid, ethyl 4-p-bromobenzyloxybenzoate, and ethyl 4-o-methoxybenzyloxyphenyl acetate exhibited the most favorable spectrum of activity.