13335-55-2

Upstream product

• 7182-47-0 2,4-dihydroxy-β-cyanopropiophenone 
• 14617-14-2 1-(2,4-dihydroxy-phenyl)-3-dimethylamino-propan-1-one; hydrochloride 
• 108-46-3 recorcinol 
• 14563-41-8 4-(2,4-dimethoxy-phenyl)-4-oxo-butyric acid methyl ester 
• 151-10-0 1,3-Dimethoxybenzene 
• 67-56-1 methanol 
• 13335-54-1 4-(2,4-dihydroxy-phenyl)-4-oxo-butyric acid 

Downstream Products

• 14328-05-3 4,5-Dihydroxy-4,5-bis-<2,4-dihydroxy-phenyl>-octan-1,8-disaeure-dimethylester 
• 13335-56-3 3-(2-Hydroxy-4-benzyloxybenzoyl)-propionsaeuremethylester 
• 161224-67-5 4-[2-hydroxy-4-(tetrahydro-pyran-2-yloxy)-phenyl]-4-oxo-butyric acid methyl ester 
• 1196475-31-6 4-oxo-4-[4-(tetrahydro-pyran-2-yloxy)-2-trifluoromethanesulfonyloxy-phenyl]-butyric acid methyl ester 
• 13335-60-9 p-Brom-benzol-sulfonsaeure-<4-(2-methoxy-4-hydroxy-phenyl)-butyl-(1)>-ester 
• 13335-57-4 3-(2-Methoxy-4-benzyloxybenzoyl)-propionsaeuremethylester 
• 13335-58-5 γ-(2-Methoxy-4-hydroxyphenyl)-buttersaeuremethylester 
• 13335-59-6 4-(2-Methoxy-4-hydroxy-phenyl)-butanol-⁽¹⁾ 
• 13204-59-6 6-Methoxy-spiro<4.5>deca-6,9-dien-8-on 

Relevant academic research and scientific papers

Fluorescent molecular probes III. 2',7'-bis-(3-carboxypropyl)-5-(and-6)-carboxyfluorescein (BCPCF): A new polar dual-excitation and dual-emission pH indicator with a pKa or 7.0

2',7'-Bis-(3-carboxypropyl)-5-(and-6)-carboxyfluorescein (BCPCF) was prepared and characterized as a new polar dual-excitation and dual-emission pH indicator with a pKa of 7.0.

BORON-CONTAINING SMALL MOLECULES

This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.

Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors

The involvement of μ-calpain in neurological disorders, such as stroke and Alzheimer's disease has attracted considerable interest in the use of calpain inhibitors as therapeutic agents. 4-Aryl-4-oxobutanoic acid amide derivatives 4 were designed as acyclic variants of μ-calpain inhibitory chromone and quinolinone derivatives. Of the compounds synthesized, 4c-2, which possesses a 2-methoxymethoxy group at the phenyl ring and a primary amide at the warhead region most potently inhibited μ-calpain (IC50 = 0.34 μM). Our findings suggest that the 4-aryl-4-oxobutanoic acid amide derivatives should be considered as a new family of μ-calpain inhibitors.