133350-15-9Relevant academic research and scientific papers
Phosphorous acid-catalyzed alkylation of phenols with alkenes
Wu, Shaofeng,Dong, Jianyu,Zhou, Dan,Wang, Wan,Liu, Long,Zhou, Yongbo
, p. 14307 - 14314 (2020/01/31)
A H3PO3-catalyzed alkylation of phenols with alkenes is achieved in a facile, efficient, and selective manner. The reaction shows a unique selectivity, i.e., excellent regioselectivity, thorough suppression of overalkylation, without alkylation of a simple phenyl ring, and can selectively provide ortho-, meta-, or para-alkylated phenol derivatives in good to excellent yields. This feature along with mild reaction conditions, sensitive functional group tolerance, and scale-up synthesis and late modification of phenolic bioactive compounds make it an ideal and practical alternative for the modification of phenols.
N-benzotriazoles: Preparation and Use in Synthesis
Katritzky, Alan R.,Lan, Xiangfu,Lam, Jamshed N.
, p. 1819 - 1826 (2007/10/02)
Methoxybenzenes and -naphthalenes are benzotriazolylmethylated in the para-position or if this is blocked in an ortho-position.The methylene groups in the products are readily substituted by electrophiles via the lithiated derivatives.Displacement ot the benzotriazole group can be effected by organometallic reagents or by electron-rich benzoid compounds to afford a versatile method for the synthesis of substituted aryl ethers.Key Words: Lithiation/ Grignard reaction/ Condensation/ Aryl ethers/ Diarylmethanes
