1333500-36-9

Basic information

• Product Name: 4,6-diamino-2-ethyl-2-methyl-1,2-dihydro-1-(4'-methoxybenzyl)-1,3,5-triazine hydrochloride
• Synonyms: 4,6-diamino-2-ethyl-2-methyl-1,2-dihydro-1-(4'-methoxybenzyl)-1,3,5-triazine hydrochloride
• CAS NO: 1333500-36-9
• Molecular Weight: 311.815
• Mol File: 1333500-36-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4,6-diamino-2-ethyl-2-methyl-1,2-dihydro-1-(4'-methoxybenzyl)-1,3,5-triazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-diamino-2-ethyl-2-methyl-1,2-dihydro-1-(4'-methoxybenzyl)-1,3,5-triazine hydrochloride(1333500-36-9)
• EPA Substance Registry System: 4,6-diamino-2-ethyl-2-methyl-1,2-dihydro-1-(4'-methoxybenzyl)-1,3,5-triazine hydrochloride(1333500-36-9)

Safety Data

• Hazardous Substances Data: 1333500-36-9(Hazardous Substances Data)

Upstream product

• 2393-23-9 4-methoxy-benzylamine 
• 17061-61-9 4-methoxybenzylamine hydrochloride 
• 4767-41-3 N₁-(4-methoxy)benzyl biguanide hydrochloride 
• 78-93-3 butanone 

Relevant articles and documents

Synthesis and antimicrobial activity of N1-benzyl or N 1-benzyloxy-1,6-dihydro-1,3,5-triazine-2,4-diamines

The emergence and spread of multidrug-resistant strains of Staphylococcus aureus and Mycobacterium tuberculosis are generating a threat to public health worldwide. In the current study, a series of N1-benzyl and N 1-benzyloxy-1,6-dihydro-1,3,5-triazine-2,4-diamine derivatives were synthesized and investigated for their antimicrobial activity against S. aureus, and Mycobacterium smegmatis which is taxonomically related to M. tuberculosis. Most of the compounds exhibited good activity against M. smegmatis as determined by comparison of diameters of the zone of inhibition of test compounds and standard antibiotics. Compound 7o showed potent antimycobacterial activity against M. smegmatis without mammalian DHFR inhibition liability. The results from this study indicate that 1-benzyl derivatives of 1,6-dihydro-1,3,5- triazine-2,4-diamines may be used as lead compounds for the discovery of antimycobacterial agents.