17061-61-9

Basic information

• Product Name: 4-METHOXYBENZYLAMINE HYDROCHLORIDE
• Synonyms: 4-METHOXYBENZYLAMINE HYDROCHLORIDE;BenzeneMethanaMine, 4-Methoxy- (hydrochloride)(1:1);[[4-Methoxyphenyl]methyl]amine hydrochloride;(4-methoxyphenyl)methanamine hydrochloride
• CAS NO: 17061-61-9
• Molecular Formula: C₈H₁₁NO*ClH
• Molecular Weight: 173.63998
• Mol File: 17061-61-9.mol
• Article Data: 50

Chemical Properties

• Melting Point: 243-244℃
• Boiling Point: 236.5°Cat760mmHg
• Flash Point: 98.8°C
• Appearance: /
• Density: 1.028g/cm³
• CAS DataBase Reference: 4-METHOXYBENZYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXYBENZYLAMINE HYDROCHLORIDE(17061-61-9)
• EPA Substance Registry System: 4-METHOXYBENZYLAMINE HYDROCHLORIDE(17061-61-9)

Safety Data

• Hazardous Substances Data: 17061-61-9(Hazardous Substances Data)

Usage

General Description

4-Methoxybenzylamine hydrochloride is a chemical compound derived from benzylamine, which is commonly used in organic synthesis. It is a white solid with a molecular formula of C8H11NO and a molecular weight of 137.18 g/mol. 4-METHOXYBENZYLAMINE HYDROCHLORIDE is often utilized as a reagent in the preparation of various pharmaceuticals and agrochemicals. It is also used as a building block in the synthesis of dyes and pigments. 4-Methoxybenzylamine hydrochloride is known for its role as an intermediate in the production of a wide range of organic compounds and has applications in various industries.

Upstream product

• 767-00-0 4-cyanophenol 
• 874-90-8 4-methoxybenzonitrile 
• 77-78-1 dimethyl sulfate 
• 29559-26-0 (p-methoxyphenyl)nitromethane 
• 100-07-2 4-methoxy-benzoyl chloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 2393-23-9 4-methoxy-benzylamine 
• 1849-02-1 2-chloro-1-methyl-benzimidazole 
• 3424-93-9 4-methoxyphenylacetamide 
• 1258944-85-2 MeO(C₆H₄)CH₂N(SiMe₂Ph)2 
• 6343-93-7 2-(4-methoxyphenyl)acetamide 

Downstream Products

• 470690-99-4 [2-mercapto-1-(4-methoxybenzyl)-1H-imidazol-5-yl]methanol 
• 470691-09-9 3-(4-methoxy-benzyl)-2-methylsulfanyl-3H-imidazole-4-carbaldehyde 
• 470691-03-3 5-hydroxymethyl-1-(4-methoxybenzyl)-2-methylthioimidazole 
• 470691-10-2 2-ethylsulfanyl-3-(4-methoxy-benzyl)-3H-imidazole-4-carbaldehyde 
• 470691-11-3 3-(4-methoxy-benzyl)-2-propylsulfanyl-3H-imidazole-4-carbaldehyde 
• 470691-04-4 [2-ethylsulfanyl-3-(4-methoxy-benzyl)-3H-imidazol-4-yl]-methanol 
• 470691-05-5 [3-(4-methoxy-benzyl)-2-propylsulfanyl-3H-imidazol-4-yl]-methanol 
• 470691-15-7 2-azido-3-[3-(4-methoxy-benzyl)-2-methylsulfanyl-3H-imidazol-4-yl]-acrylic acid ethyl ester 
• 470691-16-8 2-azido-3-[2-ethylsulfanyl-3-(4-methoxy-benzyl)-3H-imidazol-4-yl]-acrylic acid ethyl ester 
• 470691-17-9 2-azido-3-[3-(4-methoxy-benzyl)-2-propylsulfanyl-3H-imidazol-4-yl]-acrylic acid ethyl ester 
• 101190-70-9 N₁-(4-methoxybenzyl)-cyanoguanidine 
• 1333500-40-5 7,9-diamino-10-(4'-methoxybenzyl)-6,8,10-triazaspiro[4.5]deca-6,8-diene hydrochloride 
• 1333500-44-9 C₁₆H₂₃N₅O*ClH 
• 1333500-36-9 4,6-diamino-2-ethyl-2-methyl-1,2-dihydro-1-(4'-methoxybenzyl)-1,3,5-triazine hydrochloride 

Relevant articles and documents

Deoxygenative hydroboration of primary, secondary, and tertiary amides: Catalyst-free synthesis of various substituted amines

Transformation of relatively less reactive functional groups under catalyst-free conditions is an interesting aspect and requires a typical protocol. Herein, we report the synthesis of various primary, secondary, and tertiary amines through hydroboration of amides using pinacolborane under catalyst-free and solvent-free conditions. The deoxygenative hydroboration of primary and secondary amides proceeded with excellent conversions. The comparatively less reactive tertiary amides were also converted to the corresponding N,N-diamines in moderate yields under catalyst-free conditions, although alcohols were obtained as a minor product.

Base-Catalyzed Hydrosilylation of Nitriles to Amines and Esters to Alcohols

Base-catalyzed hydrosilylation of nitriles to amines and esters to silylated alcohols is reported. This protocol tolerates electron-rich and electron-neutral olefins and works in the presence of basic functional groups (e. g. tertiary amines) but fails for acidic substrates, such as phenols and NH anilines. This catalytic system does not tolerate carbonyl groups, such as aldehydes, ketones, esters and carbamides, which are reduced to corresponding alcohols and amines. With the exact amount of silane, esters can be selectively reduced in the presence of nitriles, but the selectivity drops for the pairs ester/carboxamide and carboxamide/nitrile. Through competition experiments, the following preference in functional group reactivity was determined: ester > carboxamide > nitrile.

Deoxygenation of primary amides to amines with pinacolborane catalyzed by Ca[N(SiMe3)2]2(THF)2

Deoxygenative reduction of amides is a challenging but favorable synthetic method of accessing amines. In the presence of a catalytic amount of Ca[N(SiMe3)2]2(THF)2, pinacolborane (HBpin) could efficiently reduce a broad scope of amides, primary amides in particular, into corresponding amines. Functional groups and heteroatoms showed good tolerance in this process of transformation, and a plausible reaction mechanism was proposed.