1333508-96-5

Basic information

• Product Name: 2-nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine
• Synonyms: 2-NITRO-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE;Pyrazolo[1,5-a]pyrazine, 4,5,6,7-tetrahydro-2-nitro-
• CAS NO: 1333508-96-5
• Molecular Formula: C₆H₈N₄O₂
• Molecular Weight: 168.15512
• Mol File: 1333508-96-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine(1333508-96-5)
• EPA Substance Registry System: 2-nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine(1333508-96-5)

Safety Data

• Hazardous Substances Data: 1333508-96-5(Hazardous Substances Data)

Upstream product

• 1360057-00-6 methyl 1-(2-bromoethyl)-3-nitro-1H-pyrazole-5-carboxylate 
• 1227210-30-1 (1-(2-bromoethyl)-3-nitro-1H-pyrazole-5-yl)methanol 
• 1227210-31-2 1-(2-bromoethyl)-5-(bromomethyl)-3-nitro-1H-pyrazole 

Downstream Products

• 1333508-99-8 1-(2-amino-6,7-dihydropyrazolo[1,5-a]pyrazin-5(4H)-yl)ethanone 
• 1209487-56-8 tert-butyl 2-amino-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate 

Relevant articles and documents

BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY

The present invention relates to compounds of formula (I) useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

NOVEL COMPOUNDS

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY

The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.