1333530-06-5

Basic information

• Product Name: 5-(4-methoxyphenyl)-1H,1'H-spiro[furo[2,3-d]pyrimidine-6,5'-pyrimidine]-2,2',4,4',6'(3H,3'H,5H)-pentaone
• Synonyms: 5-(4-methoxyphenyl)-1H,1'H-spiro[furo[2,3-d]pyrimidine-6,5'-pyrimidine]-2,2',4,4',6'(3H,3'H,5H)-pentaone
• CAS NO: 1333530-06-5
• Molecular Weight: 372.294
• Mol File: 1333530-06-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(4-methoxyphenyl)-1H,1'H-spiro[furo[2,3-d]pyrimidine-6,5'-pyrimidine]-2,2',4,4',6'(3H,3'H,5H)-pentaone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-methoxyphenyl)-1H,1'H-spiro[furo[2,3-d]pyrimidine-6,5'-pyrimidine]-2,2',4,4',6'(3H,3'H,5H)-pentaone(1333530-06-5)
• EPA Substance Registry System: 5-(4-methoxyphenyl)-1H,1'H-spiro[furo[2,3-d]pyrimidine-6,5'-pyrimidine]-2,2',4,4',6'(3H,3'H,5H)-pentaone(1333530-06-5)

Safety Data

• Hazardous Substances Data: 1333530-06-5(Hazardous Substances Data)

Upstream product

• 67-52-7 BARBITURIC ACID 
• 123-11-5 4-methoxy-benzaldehyde 

Relevant articles and documents

New strategy for the synthesis of 5-Aryl-1H,1′H-spiro[furo[2,3-d] pyrimidine-6,5′-pyrimidine]2,2′,4,4′,6′(3H,3'H,5H) -pentaones and their sulfur analogues

Reaction of barbituric acid (BA), 1,3-dimethyl barbituric acid (DMBA) and 2-thiobarbituric acid (TBA) with cyanogen bromide and aldehydes in the presence of L-(+)-tartaric acid afforded a new route for the synthesis of stable heterocyclic 5-aryl-1H,1′H-spiro[furo[2,3-d]pyrimidine-6,5′- pyrimidine]2,2′,4,4′,6′(3H,3′H,5H)- pentaones which is a dimeric form of barbiturate (uracil and thiouracil derivative). In the reaction of 1,3-diethyl thiobarbituric acid (DETBA) the Knoevenagel condensation and then Michael adducts were obtained under the same condition. Structure elucidation is carried out by 1H NMR, 13C NMR, FT-IR and Mass analyses. Mechanism of the formation is discussed.