133384-82-4

Basic information

• Product Name: N-phthalyl-4-fluoro-4-benzyloxycarbonyl-glutamic acid, α-methyl, γ-benzyl diester
• Synonyms: N-phthalyl-4-fluoro-4-benzyloxycarbonyl-glutamic acid, α-methyl, γ-benzyl diester
• CAS NO: 133384-82-4
• Molecular Weight: 533.51
• Mol File: 133384-82-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-phthalyl-4-fluoro-4-benzyloxycarbonyl-glutamic acid, α-methyl, γ-benzyl diester(CAS DataBase Reference)
• NIST Chemistry Reference: N-phthalyl-4-fluoro-4-benzyloxycarbonyl-glutamic acid, α-methyl, γ-benzyl diester(133384-82-4)
• EPA Substance Registry System: N-phthalyl-4-fluoro-4-benzyloxycarbonyl-glutamic acid, α-methyl, γ-benzyl diester(133384-82-4)

Safety Data

• Hazardous Substances Data: 133384-82-4(Hazardous Substances Data)

Upstream product

• 100-51-6 benzyl alcohol 
• 26878-24-0 methyl 2-phthalimidoacrylate 
• 133384-81-3 dibenzyl 2-fluoromalonate 

Relevant articles and documents

SYNTHESIS OF 5,5'-DIHYDROXYLEUCINE AND 4-FLUORO-5,5'-DIHYDROXYLEUCINE, THE REDUCTION PRODUCTS OF 4-CARBOXYGLUTAMIC AND 4-CARBOXY-4-FLUOROGLUTAMIC ACIDS

Schemes for the synthesis of 5,5'-dihydroxyleucine 3 and its 4-fluoro analog 7 involving the condensation of a suitable 'aminoacid moiety' with 2,2-dimethyl-5-iodomethyl-1,3-dioxane 15D or its fluoro analog 27A were tested.The anion of the ethyl N-diphenylmethylene-glycinate 25 gave better yields of 3 than the classical anion of diethyl acetamidomalonate.This strategy could not be successfully applied to the synthesis of 7, which could be prepared by reduction of a suitably protected 4-fluoro-4-carboxyglutamate with BMS.