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1-(5-Chloro-2-nitro-phenyl)-pyrrolidine is a chemical compound with a phenyl ring featuring a chlorine atom and a nitro group, as well as a pyrrolidine ring. 1-(5-CHLORO-2-NITRO-PHENYL)-PYRROLIDINE is known for its potentially explosive characteristics due to the presence of the nitro group, which also influences its reactivity. However, comprehensive data on its properties, such as melting point, boiling point, and density, and its applications in various industries or scientific research are not widely documented. It is essential to handle 1-(5-CHLORO-2-NITRO-PHENYL)-PYRROLIDINE with caution to prevent any hazards or adverse health impacts.

133387-30-1

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133387-30-1 Usage

Uses

Due to the limited information available on the applications of 1-(5-Chloro-2-nitro-phenyl)-pyrrolidine, it is challenging to provide a detailed list of its uses across different industries. However, given its chemical structure and potential reactivity, it may be utilized in the following areas:
Used in Chemical Synthesis:
1-(5-Chloro-2-nitro-phenyl)-pyrrolidine may be used as an intermediate or a building block in the synthesis of more complex organic compounds, particularly in pharmaceutical or agrochemical industries. Its reactivity could be harnessed to form new molecules with desired properties.
Used in Research and Development:
In academic or industrial research settings, 1-(5-Chloro-2-nitro-phenyl)-pyrrolidine could be employed as a subject of study to understand its chemical behavior, reactivity, and potential applications. This may include exploring its use in catalysis, material science, or as a probe in mechanistic studies.

Check Digit Verification of cas no

The CAS Registry Mumber 133387-30-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,3,8 and 7 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 133387-30:
(8*1)+(7*3)+(6*3)+(5*3)+(4*8)+(3*7)+(2*3)+(1*0)=121
121 % 10 = 1
So 133387-30-1 is a valid CAS Registry Number.

133387-30-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(5-Chloro-2-nitrophenyl)pyrrolidine

1.2 Other means of identification

Product number -
Other names 4-chloro-2-pyrrolidino-1-nitrobenzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:133387-30-1 SDS

133387-30-1Relevant articles and documents

Sulfonamide compound as sodium channel blocker and application thereof

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Paragraph 0057-0061; 0150-0154, (2021/05/08)

The invention provides a sulfonamide compound as a sodium channel blocker and an application of the sulfonamide compound, and the sulfonamide compound has dual inhibitory activity on Nav1.7 and Nav1.3 at the same time and can be used as a medicine for tre

INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES

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Paragraph 001457-001459, (2021/12/28)

Provided herein are heteroaryl inhibitors of fibroblast growth factor receptor kinases, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

Tert-amino effect-promoted rearrangement of aryl isothiocyanate: A versatile approach to benzimidazothiazepines and benzimidazothioethers

Geng, Xinyu,Liu, Siyuan,Qu, Jingping,Wang, Baomin,Wang, Wenyao

, p. 12635 - 12643 (2020/11/09)

A general and practical approach to benzimidazothiazepine and benzimidazothioether derivatives via an intramolecular nucleophilic addition/ring expansion rearrangement of aryl isothiocyanates promoted by the tert-amino effect has been developed. This reaction is catalyzed by low-cost camphorsulfonic acid and tolerates a broad substrate scope with complete atom economy. Structurally intriguing benzimidazothiazepine and benzimidazothioether products could be easily obtained by a simple operation in good to excellent yield (up to 98%).

Cobalt-catalyzed C-N bond-forming reaction between chloronitrobenzenes and secondary amines

Toma, Gabriel,Yamaguchi, Ryohei

experimental part, p. 6404 - 6408 (2011/02/22)

Cyclic secondary amines react with mono- or dichloronitrobenzene in the presence of a catalytic amount of cobalt(II) chloride. Phosphane ligands are beneficial for the reaction, although the bite-angle effect was not strong. The nitro-substituted tertiary amines formed are important as bioactive compounds and can also be intermediates for the synthesis of substituted anilines. This work represents the first cobalt-catalyzed approach to C-N bond-forming reactions involving aromatic chlorides and cyclic secondary amines. The reaction is ortho- and para-selective, with meta-substituted halides being unreactive in this procedure. The first cobalt-catalyzed C-N bond-forming reaction involving aromatic chlorides and cyclic secondary amines is described.The reaction is ortho- and para-selective; meta-substituted halides are unreactive. Copyright

7-PHENYL-ISOQUINOLINE-5-SULFONYLAMINO DERIVATIVES AS INHIBITORS OF AKT (PROTEINKINASE B)

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Page/Page column 29, (2010/02/12)

The present invention relates to compounds Formula (I) as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.

Specific features of nucleophilic substitution in 1-chloro-3,4- dinitrobenzene

Zotova,Kushakova,Kuznetsov,Rodin,Garabadzhiu

, p. 1473 - 1476 (2007/10/03)

Effects of the solvent, temperature, and nucleophile nature on the selectivity of nucleophilic substitution in 1-chloro-3,4-dinitrobenzene were studied, and optimal conditions were found for the synthesis and isolation of particular products.

Reaction of Mono-, Di-, and Trichloronitrobenzenes with N-Methyl Substituted Cyclic Tertiary Amines under High Pressure

Ibata, Toshikazu,Shang, Muhong,Demura, Tetsuo

, p. 2717 - 2726 (2007/10/03)

The reactions of mono-, di-, and trichloronitrobenzenes with 1-methylpyrrolidine under high pressure gave products of demethylation and ring-opening through a quaternary pyrrolidinium chloride intermediate formed by the SNAr reaction.On the other hand, the reactions with 1-methylpiperidine and 4-methylmorpholine gave only demethylation products.The selectivities of the resctions of 1-methylpyrrolidine with these chloronitrobenzenes were found to be effected by the neighboring substituent to the pyrrolidinium group.

Nucleophilic Substitution Reaction of Aromatic Chlorides with Cyclic Tertiary Amines under High Pressure

Ibata, Toshikazu,Shang, Muhong,Demura, Tetsuo

, p. 359 - 362 (2007/10/02)

The reaction of p-chloronitrobenzene with N-methylpyrrolidine under high pressure gave demethylation product and ring opening products through quaternary ammonium chloride intermediate formed by the SNAr reaction.On the other hand, the reactions with N-methylpiperidine and N-methylmorpholine gave only demethylation products.The reactions of o-chloronitrobenzene and 2,4-dichloronitrobenzene with above amines gave similar results.

Aromatic Nucleophilic Substitution of Halobenzenes with Amines under High Pressure

Ibata, Toshikazu,Isogami, Yasushi,Toyoda, Jiro

, p. 42 - 49 (2007/10/02)

The nucleophilic substitution reactions of aromatic halides having electron-attracting groups on ortho or para position with various primary and secondary amines were accelerated by high pressure to give the corresponding N-substituted anilines in high yields.The bulkiness of amines affects its reactivity to lower the yields of the products.Although the secondary amines are usually less reactive than primary amines, cyclic secondary amines such as morpholine, piperidine, and pyrrolidine were found very reactive. 1,4-Diazabicyclooctane and quinuclidine gave N-quarternary ammonium halides in high yields in contrast to the low reactivity of acyclic tertiary amines.Dichloro- and trichloro-nitrobenzenes also react with diethylamine, pyrrolidine, and morpholine to give mono-, di-, and trisubstitution products depending upon the amount of amine and the position of nitro group in these chlorides.

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