1333899-73-2Relevant academic research and scientific papers
Design, synthesis, and bioactivities of novel oxadiazole-substituted pyrazole oximes
Dai, Hong,Chen, Jia,Li, Gang,Ge, Shushan,Shi, Yujun,Fang, Yuan,Ling, Yong
, p. 950 - 953 (2017/02/10)
A series of novel pyrazole oxime derivatives containing a substituted oxadiazole group were designed and synthesized. The bioassay results indicated that some title compounds displayed good acaricidal and insecticidal activities against Tetranychus cinnabarinus, Aphis medicaginis, Oriental armyworm, and Nilaparvata lugens. Especially, compounds 7a, 7b, and 7c had 80%, 90%, and 90% insecticidal activities against A. medicaginis at 20 μg/mL, respectively. Interestingly, some of the designed compounds displayed wonderful fungicidal activities in vivo against cucumber Pseudoperonospora cubensis. Furthermore, compounds 7a (EC50= 4.97 μg/mL) and 7h (EC50= 0.51 μg/mL) showed excellent fungicidal activity against P. cubensis comparable or better than that of the control Pyraclostrobin (EC50= 4.59 μg/mL).
Design, synthesis, and biological activities of novel pyrazole oxime compounds containing a substituted pyridyl moiety
Chen, Cuili,Chen, Jia,Gu, Haiying,Bao, Ning,Dai, Hong
, (2017/06/19)
In this paper, in order to find novel biologically active pyrazole oximes, a series of pyrazole oxime compounds bearing a substituted pyridyl unit were prepared. Bioassays showed that some target compounds were found to have good acaricidal activity against Tetranychus cinnabarinus at a concentration of 500 μg/mL, compound 9q especially displayed potent acaricidal activity against T. cinnabarinus when the concentration was reduced to 100 μg/mL. Interestingly, most target compounds possessed excellent insecticidal activities against Oriental armyworm at 500 μg/mL. Moreover, some compounds were active against Aphis medicaginis and Nilaparvata lugens at 500 μg/mL. Additionally, compounds 9b, 9g, 9l, 9p, 9q, 9r, 9s, 9t, 9u, and 9v displayed significant antiproliferative activities against HepG2 cells with IC50 values of 1.53-17.27 μM, better than that of the control 5-fluorouracil (IC50 = 35.67 μM).
Design, synthesis, and antibacterial evaluation of new Schiff's base derivatives bearing nitroimidazole and pyrazole nuclei as potent E. coli FabH inhibitors
Sangani, Chetan B.,Makwana, Jigar A.,Duan, Yong-Tao,Tarpada, Umesh P.,Patel, Yogesh S.,Patel, Ketan B.,Dave, Vivek N.,Zhu, Hai-Liang
, p. 10137 - 10149 (2016/01/12)
New Schiff's base derivatives 5a-j have been synthesized by reaction between 5-aryloxypyrazole-4-carbaldehydes 3a-j and 2-(2-methyl-5-nitro-1Himidazol- 1-yl)acetohydrazide 4 in the presence of nickel (II) nitrate as a catalyst in ethanol at room temperatu
One step synthesis of pyrido[1,2-a]benzimidazole derivatives of aryloxypyrazole and their antimicrobial evaluation
Jardosh, Hardik H.,Sangani, Chetan B.,Patel, Manish P.,Patel, Ranjan G.
, p. 123 - 126 (2013/06/26)
A new series of pyrido[1,2-a]benzimidazole derivatives bearing the aryloxypyrazole nucleus have been synthesized by base-catalyzed cyclocondensation reaction through multi-component reaction (MCR) approach. All the synthesized compounds were investigated
Microwave-assisted synthesis of novel 4H-chromene derivatives bearing phenoxypyrazole and their antimicrobial activity assessment
Sangani, Chetan B.,Shah, Nimesh M.,Patel, Manish P.,Patel, Ranjan G.
, p. 1165 - 1174 (2012/11/13)
A new series of 4H-chromene derivatives 4a-p bearing the 5-phenoxypyrazole nucleus were synthesized under microwave irradiation by the reaction of 5-phenoxypyrazole-4-carbaldehydes 1a-h, malononitrile 2 and compounds 1,3-cyclohexanedione and dimedone (3a
Synthesis and antimicrobial screening of pyrano[3,2-c]chromene derivatives of 1H-pyrazoles
Sangani, Chetan B.,Mungra, Divyesh C.,Patel, Manish P.,Patel, Ranjan G.
, p. 635 - 647 (2012/04/23)
A new series of twenty four derivatives of pyrano[3,2-c]chromene IVa-x bearing 1H-pyrazole were synthesized by a one pot, base-catalyzed cyclocondensation reaction of 1H-pyrazole-4-carbaldehyde Ia-l, malononitrile II and 4-hydroxycoumarin IIIa-b. All the synthesized compounds were characterized by elemental analysis, FT-IR, 1H NMR and 13C NMR spectral data. All the synthesized compounds were screened against six bacterial pathogens, namely B. subtilis, C. tetani, S. pneumoniae, S. typhi, V. cholerae, E. coli and for antifungal activity against two fungal pathogens, A. fumigatus and C. albicans using the broth microdilution MIC method. Some of the compounds were found to be equipotent or more potent than commercial drugs against most of employed strains, as evident from the screening data. Versita Sp. z o.o.
